Detailed information of TA system TA151224

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2282528..2284116
• Replicon: chromosome
• Accession: NZ_CP049343
• Organism: Escherichia coli strain UMB200201_11

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: FM734_RS10970
• Protein ID: WP_001125463.1
• Coordinates: 2282794..2284116 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FM734_RS10965
• Protein ID: WP_001296726.1
• Coordinates: 2282528..2282794 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FM734_RS10965	2282528..2282794	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
FM734_RS10970	2282794..2284116	+	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
FM734_RS10975	2284427..2284635	+	209	Protein_2141	helix-turn-helix transcriptional regulator	-
FM734_RS10980	2285069..2285632	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
FM734_RS10985	2285993..2286703	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T151224 WP_001125463.1 NZ_CP049343:2282794-2284116 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T151224 NZ_CP065397:562318-562545 [Bifidobacterium longum]
ATGAAGAAGCTGGATCGTAATGTTGCCAAGAGAATCATCGCAAAGCTTAGGGAAATTTCACAGTTGGAAGATCCGAGAAG
CACCGGCAAGGCTCTTGCCGGTAATCTGGCAGGGCTGTGGCGTTACCGTGTCGGGGACTATCGTATCGTGTGCGATATAG
AGGATGAGGTTCTGCTGATTCTTGTGATTGATGTCGCGCACAGGAGCAAGGTGTACAAGCGTTGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT151224 WP_001296726.1 NZ_CP049343:2282528-2282794 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT151224 NZ_CP065397:562056-562292 [Bifidobacterium longum]
ATGGCCACGGTTACTGCAGCATTAAGGATGCCTGTCGAATTGGCGGCTCGTTACGATTGTCTGGCGAAAGCGACTGGTCG
TACGAAGACGTTTTACATGAACGAAGCCCTTACCGAATCGATCGATAGGTTTGAGTATGAATACGGCATTATGAAAAAGG
TCGAGGATTGGCGTGCCGGCAGACTCGAAACCGTGACGCTCGACGAGCTGGAGGAAAGCCTTGGCTTGGAGGATTGA

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0