Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 563899..564535 Replicon chromosome
Accession NZ_CP049330
Organism Bacillus licheniformis strain CP6

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag G6536_RS02795 Protein ID WP_003179128.1
Coordinates 564185..564535 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag G6536_RS02790 Protein ID WP_006638778.1
Coordinates 563899..564180 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6536_RS02770 559014..560495 + 1482 WP_009330132.1 PH domain-containing protein -
G6536_RS02775 560492..561091 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
G6536_RS02780 561434..562393 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
G6536_RS02785 562618..563787 + 1170 WP_025807384.1 alanine racemase -
G6536_RS02790 563899..564180 + 282 WP_006638778.1 hypothetical protein Antitoxin
G6536_RS02795 564185..564535 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
G6536_RS02800 564653..565480 + 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
G6536_RS02805 565484..565849 + 366 WP_003179132.1 STAS domain-containing protein -
G6536_RS02810 565852..566253 + 402 WP_003179135.1 anti-sigma regulatory factor -
G6536_RS02815 566264..567271 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
G6536_RS02820 567330..567656 + 327 WP_003179140.1 anti-sigma factor antagonist -
G6536_RS02825 567656..568141 + 486 WP_003179142.1 anti-sigma B factor RsbW -
G6536_RS02830 568107..568898 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
G6536_RS02835 568895..569494 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T151208 WP_003179128.1 NZ_CP049330:564185-564535 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T151208 NZ_CP065383:c2937737-2937474 [Atribacter laminatus]
ATGAATTACCAGATTCTGTGGCATAAAGATGCGGTTCAGGATTTAAAAAAAATTGACCGAAAAATTGCATTATCAATCAT
AAGTAAAGTTGAAAAATATTTAGCTCGAGATCCAATAAAACTTAGTATGCCACTCAAGGGCAATTTCAAGGGATTCTTTC
GATACCGTATAGGAAAGTTTCGTGTTATTTATACAATTCAGGAAAATCATCTTCTTATATTGGTATTAAAGGTTGGGAAA
AGGGATGAGGTATATGATGAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT151208 WP_006638778.1 NZ_CP049330:563899-564180 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT151208 NZ_CP065383:c2937943-2937734 [Atribacter laminatus]
ATGATATCTATTCGTTTACCTAAAGATCTTGAAAAAAAGTTAGATATATTAGCTCAATCAACAAAACGATCCAAGAGCTT
TTATGTTAAGGAAGCTTTGACTCGTTATCTCGAAGATATTGAGGATTATTATGTTGTGCTTGAAAGGTTTTCCCAACCAG
GAAGTGACTACTATACAACCGAAGAAGTTAAAAAAGAAATTGAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References