Detailed information of TA system TA151206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 240131..241869
• Replicon: plasmid pSBC2-4
• Accession: NZ_CP049320
• Organism: Caballeronia sp. SBC2

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: SBC2_RS39510
• Protein ID: WP_165107204.1
• Coordinates: 240131..241009 (+)
• Length: 293 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: SBC2_RS39515
• Protein ID: WP_165107206.1
• Coordinates: 241006..241869 (+)
• Length: 288 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBC2_RS39480	235548..236621	-	1074	WP_165107191.1	porin	-
SBC2_RS39485	237037..237354	+	318	WP_165107193.1	non-heme iron oxygenase ferredoxin subunit	-
SBC2_RS39490	237356..237685	+	330	WP_165107195.1	hypothetical protein	-
SBC2_RS39495	237720..238790	+	1071	WP_165107197.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
SBC2_RS39500	238783..239538	+	756	WP_165107199.1	SDR family oxidoreductase	-
SBC2_RS39505	239599..240126	+	528	WP_165107202.1	cupin domain-containing protein	-
SBC2_RS39510	240131..241009	+	879	WP_165107204.1	alpha/beta fold hydrolase	Toxin
SBC2_RS39515	241006..241869	+	864	WP_165107206.1	IclR family transcriptional regulator	Antitoxin
SBC2_RS39520	241866..242663	+	798	WP_165107208.1	SDR family oxidoreductase	-
SBC2_RS39525	242656..244323	+	1668	WP_165107210.1	thiamine pyrophosphate-binding protein	-
SBC2_RS39530	244316..245140	+	825	WP_165107212.1	aspartate dehydrogenase	-
SBC2_RS39535	245170..246660	+	1491	WP_165107214.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	fliM	1..377315	377315

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (44-271)

Antitoxin

• Transcription regulator IclR, C-terminal (143-266)

Sequences

Toxin

Protein

• Length: 293 a.a.
• Molecular weight: 30919.21 Da
• Isoelectric Point: 6.7744

>T151206 WP_165107204.1 NZ_CP049320:240131-241009 [Caballeronia sp. SBC2]
MTSPAFMLTHADALARFAEQRVDTAQRTIGYREAGDKHLHTMPIVMLHGIGSGAASWVRQMETLGDAHHVLAWDAPGYGK
STHVEPASPVASDYADALSDWLDALGIERCILVGHSLGAIIAGSFASRQSARVAALLLLSPAGGYGAAPEHVREEKRDAR
LAMLAELGPQGLAEKRSANMLSAGAVEDAREWVRWNMARINLAGYAQATHLLANADLASDLKHFKGRVAVAVGAEDTITP
PAACEQIAKAANVSLQVIPGAGHAGYIEAPLRYSALIEAFSTPCKQSKGVMQ

Nucleotide

• Length: 879 bp

>T151206 NZ_CP065382:1173954-1174244 [Faecalibacterium prausnitzii]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAGGACTACAAACGAGCTATAAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCACATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAAGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin

Protein

• Length: 288 a.a.
• Molecular weight: 31649.25 Da
• Isoelectric Point: 7.4631

>AT151206 WP_165107206.1 NZ_CP049320:241006-241869 [Caballeronia sp. SBC2]
MTPGTLARVADDADKDDGNYIVPGLERGLKILAEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGFLERADKDRNY
RLGVAVLRLGFEYLSSLELTDLGLPIIEGLRTSTGLTSHILIRDGRDVVFVAKAQSQEPIFSSVKVNVGTRLPAHATTHG
HVLMGDLSLDELRTLYPERVLERYTRLTPETVEALYEMVRADAERGYAISQSSFERGISVVTAPVRNDTGRIVAVITTTI
PRPEIDATLLDTGLVDKVRHAAAELSSRLNYRPGAQSQYLKSLGLKS

Nucleotide

• Length: 864 bp

>AT151206 NZ_CP065382:1173679-1173957 [Faecalibacterium prausnitzii]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCACAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA