Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 171325..171908 Replicon plasmid pSBC2-2
Accession NZ_CP049318
Organism Caballeronia sp. SBC2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SBC2_RS27435 Protein ID WP_165102153.1
Coordinates 171654..171908 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag SBC2_RS27430 Protein ID WP_165102150.1
Coordinates 171325..171657 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBC2_RS27415 166627..167019 - 393 WP_165102134.1 helix-turn-helix domain-containing protein -
SBC2_RS27420 167123..170179 + 3057 WP_165102156.1 toprim domain-containing protein -
SBC2_RS27425 170179..171210 + 1032 WP_165102147.1 site-specific tyrosine recombinase XerC -
SBC2_RS27430 171325..171657 - 333 WP_165102150.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SBC2_RS27435 171654..171908 - 255 WP_165102153.1 type II toxin-antitoxin system HicA family toxin Toxin
SBC2_RS27440 172782..173423 + 642 WP_165104850.1 RHS repeat-associated core domain-containing protein -
SBC2_RS27445 173430..173951 + 522 WP_165102165.1 hypothetical protein -
SBC2_RS27450 174241..174693 + 453 WP_165102168.1 RHS repeat-associated core domain-containing protein -
SBC2_RS27455 175047..175268 - 222 WP_165102171.1 type I toxin-antitoxin system SymE family toxin -
SBC2_RS27460 175374..175682 - 309 WP_165102174.1 helix-turn-helix domain-containing protein -
SBC2_RS27465 175899..176120 + 222 WP_031362537.1 YdcH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG / gnd 1..1831039 1831039


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9433.94 Da        Isoelectric Point: 10.9436

>T151204 WP_165102153.1 NZ_CP049318:c171908-171654 [Caballeronia sp. SBC2]
MKRAHTKTLELIFARPVSANVRWADIEALFLELGATITEREGSRIAVVLFGQVQVYHRPHPRPTTDKGAIASVRKWLESN
GVKP

Download         Length: 255 bp

>T151204 NZ_CP065374:c3727774-3727493 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12163.65 Da        Isoelectric Point: 4.5594

>AT151204 WP_165102150.1 NZ_CP049318:c171657-171325 [Caballeronia sp. SBC2]
MNILSIDNYRAVVTYDPDTDMLRGEFLGLNGGADFYASDIPTLKTEGAKSLAVFLDVCRENGIDPVRHFSGRFNARIDPE
LHARAVETAAAEGISLNQLIERAIEHEVRT

Download         Length: 333 bp

>AT151204 NZ_CP065374:c3727998-3727771 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References