Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 163759..164342 Replicon plasmid pSBC2-2
Accession NZ_CP049318
Organism Caballeronia sp. SBC2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SBC2_RS27395 Protein ID WP_165102153.1
Coordinates 164088..164342 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag SBC2_RS27390 Protein ID WP_165102150.1
Coordinates 163759..164091 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBC2_RS27365 159277..159675 - 399 WP_147408238.1 hypothetical protein -
SBC2_RS27370 159921..161486 - 1566 WP_206366151.1 transposase -
SBC2_RS27375 161557..161736 - 180 WP_165102141.1 hypothetical protein -
SBC2_RS27380 161904..162182 - 279 WP_165102144.1 hypothetical protein -
SBC2_RS27385 162613..163644 + 1032 WP_165102147.1 site-specific tyrosine recombinase XerC -
SBC2_RS27390 163759..164091 - 333 WP_165102150.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SBC2_RS27395 164088..164342 - 255 WP_165102153.1 type II toxin-antitoxin system HicA family toxin Toxin
SBC2_RS27400 165216..165470 + 255 Protein_138 RHS repeat-associated core domain-containing protein -
SBC2_RS27405 165477..165860 + 384 WP_165104849.1 toxin C-terminal domain-containing protein -
SBC2_RS27410 166301..166522 - 222 WP_165102130.1 type I toxin-antitoxin system SymE family toxin -
SBC2_RS27415 166627..167019 - 393 WP_165102134.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG / gnd 1..1831039 1831039


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9433.94 Da        Isoelectric Point: 10.9436

>T151203 WP_165102153.1 NZ_CP049318:c164342-164088 [Caballeronia sp. SBC2]
MKRAHTKTLELIFARPVSANVRWADIEALFLELGATITEREGSRIAVVLFGQVQVYHRPHPRPTTDKGAIASVRKWLESN
GVKP

Download         Length: 255 bp

>T151203 NZ_CP065374:c2521616-2521338 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12163.65 Da        Isoelectric Point: 4.5594

>AT151203 WP_165102150.1 NZ_CP049318:c164091-163759 [Caballeronia sp. SBC2]
MNILSIDNYRAVVTYDPDTDMLRGEFLGLNGGADFYASDIPTLKTEGAKSLAVFLDVCRENGIDPVRHFSGRFNARIDPE
LHARAVETAAAEGISLNQLIERAIEHEVRT

Download         Length: 333 bp

>AT151203 NZ_CP065374:c2521326-2521021 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCCGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References