Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 115774..116413 Replicon plasmid pSBC2-2
Accession NZ_CP049318
Organism Caballeronia sp. SBC2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SBC2_RS27170 Protein ID WP_165102035.1
Coordinates 115774..116190 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SBC2_RS27175 Protein ID WP_165102037.1
Coordinates 116177..116413 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBC2_RS27155 112081..112764 + 684 WP_165102030.1 hypothetical protein -
SBC2_RS27160 112918..113958 - 1041 WP_165102031.1 FUSC family protein -
SBC2_RS27165 114279..115727 + 1449 WP_165102033.1 NAD-dependent succinate-semialdehyde dehydrogenase -
SBC2_RS27170 115774..116190 - 417 WP_165102035.1 type II toxin-antitoxin system VapC family toxin Toxin
SBC2_RS27175 116177..116413 - 237 WP_165102037.1 DNA-binding protein Antitoxin
SBC2_RS27180 116602..119319 - 2718 WP_165102039.1 aconitate hydratase AcnA -
SBC2_RS27185 119392..120843 - 1452 WP_165102041.1 bifunctional 2-methylcitrate dehydratase/aconitate hydratase -
SBC2_RS27190 120869..121405 - 537 WP_165102044.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG / gnd 1..1831039 1831039


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15448.82 Da        Isoelectric Point: 7.3198

>T151202 WP_165102035.1 NZ_CP049318:c116190-115774 [Caballeronia sp. SBC2]
VYLIDTNVISEIRKGANANKGVRKLFKRIGKDEIRLHLSAVTMGELRRGTEAVRHRGDAPQAAMLEAWLGTILDDYAMDV
ISIDDDVAQLWGRLRVPNPENPIDKLIAATALMHDLTVVTRNTKDFEKTGVKLLNPFE

Download         Length: 417 bp

>T151202 NZ_CP065374:c1491871-1491116 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATGCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAACTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8509.58 Da        Isoelectric Point: 5.6939

>AT151202 WP_165102037.1 NZ_CP049318:c116413-116177 [Caballeronia sp. SBC2]
MANLLVRGIDEALVQSLRERAAAHGRSAEAEHREILAQALSRPKKRSLAEVLASMPNVGEDADFERIQDTGGAPRVFD

Download         Length: 237 bp

>AT151202 NZ_CP065374:c1492374-1492006 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References