Detailed information of TA system TA151201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 717398..717963
• Replicon: plasmid pSBC2-1
• Accession: NZ_CP049317
• Organism: Caballeronia sp. SBC2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SBC2_RS20920
• Protein ID: WP_165096149.1
• Coordinates: 717398..717769 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SBC2_RS20925
• Protein ID: WP_165096154.1
• Coordinates: 717766..717963 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBC2_RS20900	713113..713883	-	771	WP_165096136.1	putative hydro-lyase	-
SBC2_RS20905	714286..715842	+	1557	WP_165096139.1	cache domain-containing protein	-
SBC2_RS20910	715839..716771	+	933	WP_165096143.1	LysR family transcriptional regulator	-
SBC2_RS20915	716768..717313	-	546	WP_165096146.1	GNAT family N-acetyltransferase	-
SBC2_RS20920	717398..717769	-	372	WP_165096149.1	PIN domain-containing protein	Toxin
SBC2_RS20925	717766..717963	-	198	WP_165096154.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
SBC2_RS20930	718090..718992	-	903	WP_165096159.1	LysR family transcriptional regulator	-
SBC2_RS20935	719110..719997	+	888	WP_165096162.1	hypothetical protein	-
SBC2_RS20940	720028..721254	+	1227	WP_165096166.1	Xaa-Pro peptidase family protein	-
SBC2_RS20945	721316..722353	+	1038	WP_165096169.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	adeG	1..1990521	1990521

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13126.03 Da
• Isoelectric Point: 6.0637

>T151201 WP_165096149.1 NZ_CP049317:c717769-717398 [Caballeronia sp. SBC2]
MILVDTSIWIDHLRAGNAVLTDLLLSGRVLTHPFVIGELALGNLSQSDRVLESLLNLPRAVVATPEETVDFISSAALSGL
GIGYVDASLLASTRLTPDARLWTRDKRLHAAADRLGSSATVSH

Nucleotide

• Length: 372 bp

>T151201 NZ_CP065374:495652-496230 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTACTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7147.27 Da
• Isoelectric Point: 10.9435

>AT151201 WP_165096154.1 NZ_CP049317:c717963-717766 [Caballeronia sp. SBC2]
MRTTIALDDDLLAKAQAYTGLQEKSALVREALKALIERESARRLARLGGSEPKLSPIPRRQSSKA

Nucleotide

• Length: 198 bp

>AT151201 NZ_CP065374:495009-495563 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA