Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2887577..2888208 Replicon chromosome
Accession NZ_CP049316
Organism Caballeronia sp. SBC2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SBC2_RS12730 Protein ID WP_165092195.1
Coordinates 2887816..2888208 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SBC2_RS12725 Protein ID WP_165093302.1
Coordinates 2887577..2887819 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBC2_RS12705 2883382..2884791 - 1410 WP_165092193.1 sodium:proton antiporter -
SBC2_RS12710 2885031..2886221 - 1191 WP_165092194.1 nicotinate phosphoribosyltransferase -
SBC2_RS12715 2886650..2886973 + 324 WP_089159225.1 ferredoxin family protein -
SBC2_RS12725 2887577..2887819 + 243 WP_165093302.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SBC2_RS12730 2887816..2888208 + 393 WP_165092195.1 type II toxin-antitoxin system VapC family toxin Toxin
SBC2_RS12735 2888537..2889280 + 744 WP_165092196.1 FadR family transcriptional regulator -
SBC2_RS12740 2889701..2889931 + 231 Protein_2499 MFS transporter -
SBC2_RS12745 2890092..2891450 + 1359 WP_165092197.1 glucarate dehydratase -
SBC2_RS12750 2891528..2892445 + 918 WP_165092198.1 5-dehydro-4-deoxyglucarate dehydratase -
SBC2_RS12755 2892527..2893117 - 591 WP_165092199.1 LUD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14391.34 Da        Isoelectric Point: 7.4675

>T151200 WP_165092195.1 NZ_CP049316:2887816-2888208 [Caballeronia sp. SBC2]
VNYLLDTNAVIALMKGHSGFLARLRQHQPRDFAMPSIVAHELYFGAYKSRHAAGNLRRVEALQFEILDFGPEDTRRAGEA
RAQLASAGTPIGPYDVLIAGQALARSLTLVTHNMREFQRVSGLSVEDWEG

Download         Length: 393 bp

>T151200 NZ_CP065371:c884-543 [Vibrio parahaemolyticus]
ATGACATATGCAGTACCAGAGAAAGGCGATGTAGTAGTAATGAGTTTTAATCCGCAAAGCGGACACGAACAAGCGGGAGA
CAGTCGGCCTGGGCTGGTCATTTCCCCGAAAGAGTTTAACCAAGCAACTGGCTTTGCTCTGGTATGCCCCATAACCAACC
AGTCAAAAGGGTATCCGTTTGAAGTTGAAATAACCGGAAGCCAAAAAACAACGGGTGTGGTGCTGGCTGACCAAGTGAAG
TCCTTGGATTGGCGCGCGCGTCGCGCTCGTGTGGTGGACTCCGTTTCAAACGAAACACTGGGGACTGTGCGGGATTATGT
CACAGCGATTGCTAATGGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9244.37 Da        Isoelectric Point: 4.5024

>AT151200 WP_165093302.1 NZ_CP049316:2887577-2887819 [Caballeronia sp. SBC2]
MDTAKVFWSGRSQAVRLPKEFRLDADEVRIRRHGRAIILEPIASDWAWLDSVVGPIDDDFAEAAQEKLSEQDRPDLDFFK

Download         Length: 243 bp

>AT151200 NZ_CP065371:c1111-881 [Vibrio parahaemolyticus]
ATGTCACAAACAATAGCTAAGTGGGGCCACAGCGCAGCTGTGCGTATACCTTCTAAGGTATTGAAAAATATGGATATGGC
GGTGGGTGACAAAGTGGAGGTTAAAGTGTTCAATCAACAAATTATCATTGAACCTGCAAAACCAACACTCGCCCAGCTTT
TGAGTCAGATCACTGATGAAAACCGCCATGATGAAGTAATCACCGAAACTATGGGTAATGAATTGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References