Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 192324..192856 Replicon chromosome
Accession NZ_CP049316
Organism Caballeronia sp. SBC2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SBC2_RS00860 Protein ID WP_165085637.1
Coordinates 192533..192856 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SBC2_RS00855 Protein ID WP_165085634.1
Coordinates 192324..192536 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBC2_RS00830 187802..188302 - 501 WP_165085620.1 YbaK/EbsC family protein -
SBC2_RS00835 188334..189257 - 924 WP_165085623.1 hydroxymethylglutaryl-CoA lyase -
SBC2_RS00840 189326..190267 - 942 WP_165085625.1 glyoxylate/hydroxypyruvate reductase A -
SBC2_RS00845 190531..191151 + 621 WP_165085628.1 alpha/beta hydrolase -
SBC2_RS00850 191236..192243 + 1008 WP_165085631.1 sulfate ABC transporter substrate-binding protein -
SBC2_RS00855 192324..192536 + 213 WP_165085634.1 antitoxin MazE family protein Antitoxin
SBC2_RS00860 192533..192856 + 324 WP_165085637.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SBC2_RS00865 192935..193996 - 1062 WP_165085639.1 biotin synthase BioB -
SBC2_RS00870 194032..194757 - 726 WP_165085641.1 dethiobiotin synthase -
SBC2_RS00875 194754..195974 - 1221 WP_165085644.1 8-amino-7-oxononanoate synthase -
SBC2_RS00880 195971..197359 - 1389 WP_165085646.1 adenosylmethionine--8-amino-7-oxononanoate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(6-69)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11818.78 Da        Isoelectric Point: 7.0147

>T151195 WP_165085637.1 NZ_CP049316:192533-192856 [Caballeronia sp. SBC2]
VRRGDLVTVSVQGNYGKPRPALIVQSDLFSEHGSVTVLLLTSELRDTPLFRVAIEPDEINQLPKRSQVMVDKAVTMPREK
LGEVFGRLEGELMISVNRAMAVFLGIA

Download         Length: 324 bp

>T151195 NZ_CP065369:c759008-758730 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCTCTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGACGTAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGTCGATTACTAATTATTCCTGAGATTTCGATGATTATCTCTCACTGGGTCGAGGGCGACATCATCCGAGTTATG
CGTGTCCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8173.26 Da        Isoelectric Point: 6.3275

>AT151195 WP_165085634.1 NZ_CP049316:192324-192536 [Caballeronia sp. SBC2]
MRQNVAERVGKRRAALRAAGLRPVQIWVPDTRREGFAEECRRQSLLLREDSQETEILDFIEASMDTKGWE

Download         Length: 213 bp

>AT151195 NZ_CP065369:c759289-759005 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTGGCTCAACAAATGGCAGAGAGTCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAGCATTGTCTCACGATGCGTGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References