Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 474126..474779 Replicon chromosome
Accession NZ_CP049314
Organism Acinetobacter baumannii strain Ex003

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag G5571_RS02280 Protein ID WP_000931890.1
Coordinates 474390..474779 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag G5571_RS02275 Protein ID WP_001288210.1
Coordinates 474126..474383 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5571_RS02255 (G5571_00447) 469642..470649 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
G5571_RS02260 (G5571_00448) 470668..471045 + 378 WP_001216380.1 50S ribosomal protein L17 -
G5571_RS02265 (G5571_00449) 471226..472716 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
G5571_RS02270 (G5571_00450) 472766..473938 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
G5571_RS02275 (G5571_00451) 474126..474383 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
G5571_RS02280 (G5571_00452) 474390..474779 + 390 WP_000931890.1 membrane protein Toxin
G5571_RS02285 (G5571_00454) 475549..476634 + 1086 WP_000049106.1 hypothetical protein -
G5571_RS02290 (G5571_00455) 476712..477278 + 567 WP_000651536.1 rhombosortase -
G5571_RS02295 (G5571_00456) 477466..479661 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T151193 WP_000931890.1 NZ_CP049314:474390-474779 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T151193 NZ_CP065369:716974-717276 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTGTCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCGAAGCAGTTAGTACAAACGATCTTCTCTAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT151193 WP_001288210.1 NZ_CP049314:474126-474383 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT151193 NZ_CP065369:716729-716986 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCGTCCGCGTATCTCGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References