Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 100048..100691 | Replicon | plasmid pHS08-175-1 |
| Accession | NZ_CP049291 | ||
| Organism | Enterobacter hormaechei subsp. steigerwaltii strain 08-175 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q84A06 |
| Locus tag | G6324_RS24460 | Protein ID | WP_000754566.1 |
| Coordinates | 100048..100464 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q84A07 |
| Locus tag | G6324_RS24465 | Protein ID | WP_001261276.1 |
| Coordinates | 100461..100691 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6324_RS24440 (G6324_24450) | 95151..97226 | + | 2076 | WP_047929053.1 | protease Lon-related BREX system protein BrxL | - |
| G6324_RS24445 (G6324_24455) | 97334..97612 | - | 279 | Protein_104 | IS3 family transposase | - |
| G6324_RS24450 (G6324_24460) | 97629..98705 | - | 1077 | WP_000227969.1 | IS110 family transposase | - |
| G6324_RS24455 (G6324_24465) | 98987..99843 | - | 857 | Protein_106 | IS3 family transposase | - |
| G6324_RS24460 (G6324_24470) | 100048..100464 | - | 417 | WP_000754566.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| G6324_RS24465 (G6324_24475) | 100461..100691 | - | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| G6324_RS25165 | 100648..100902 | + | 255 | Protein_109 | hypothetical protein | - |
| G6324_RS24470 (G6324_24480) | 100890..101381 | - | 492 | Protein_110 | IS5-like element ISKpn26 family transposase | - |
| G6324_RS24475 (G6324_24485) | 101487..102191 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| G6324_RS24480 (G6324_24490) | 102256..102345 | - | 90 | Protein_112 | mercuric transporter MerT family protein | - |
| G6324_RS24485 (G6324_24495) | 102417..102851 | + | 435 | WP_000429836.1 | Hg(II)-responsive transcriptional regulator | - |
| G6324_RS24490 (G6324_24500) | 102930..103934 | + | 1005 | WP_000427619.1 | IS110-like element IS5075 family transposase | - |
| G6324_RS24495 (G6324_24505) | 105181..105423 | + | 243 | WP_000844627.1 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaTEM-1B / catA1 / blaSFO-1 / mph(A) / tet(A) / aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / dfrA12 / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) | - | 1..182177 | 182177 | |
| - | inside | IScluster/Tn | tet(A) / blaTEM-1B / aph(3')-Ia / catA1 / aph(3'')-Ib / aph(6)-Id / dfrA12 / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) | - | 97629..150976 | 53347 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15006.52 Da Isoelectric Point: 9.2957
>T151189 WP_000754566.1 NZ_CP049291:c100464-100048 [Enterobacter hormaechei subsp. steigerwaltii]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
Download Length: 417 bp
>T151189 NZ_CP065361:c7843-7544 [Ruegeria sp. SCSIO 43209]
ATGCGTGACATTCATCACTCTCAGGCGGCAAAATCCGACCTCGTCGATATCTGGGTCGAGACAGACCGACAGTGGGGCGA
GGCGCAGGCGGACCGCTATCTCGATGATATCGATCGCGCCCTGAAGGGTCTCATCGCCAACCCGCAAATGGGGTCTGACT
GTTCCGATCTCTTGCAGGGTGCGCGTAAACTGATCACGGGCCGGCACCTCGTGTTCTACGAGGTGGACCCGGACAGGATC
TTCGTGATCCGAGTCTTGCATCAGTCCATGGACGTGCCGAGGCATCTGCGGTCGTCCTGA
ATGCGTGACATTCATCACTCTCAGGCGGCAAAATCCGACCTCGTCGATATCTGGGTCGAGACAGACCGACAGTGGGGCGA
GGCGCAGGCGGACCGCTATCTCGATGATATCGATCGCGCCCTGAAGGGTCTCATCGCCAACCCGCAAATGGGGTCTGACT
GTTCCGATCTCTTGCAGGGTGCGCGTAAACTGATCACGGGCCGGCACCTCGTGTTCTACGAGGTGGACCCGGACAGGATC
TTCGTGATCCGAGTCTTGCATCAGTCCATGGACGTGCCGAGGCATCTGCGGTCGTCCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8721.74 Da Isoelectric Point: 4.3533
>AT151189 WP_001261276.1 NZ_CP049291:c100691-100461 [Enterobacter hormaechei subsp. steigerwaltii]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT151189 NZ_CP065361:c8087-7836 [Ruegeria sp. SCSIO 43209]
ATGGCAAGCACAAGCGTCACACTTGGCCCCCATTGGGACGAATTCATCGCCCTGATGCTTAAAGAGGGGCGTTACGGGTC
AACCAGCGAGTTGATCCGCGCCTCTCTGCGCCTGATGGAGGAGCAGGAAGGTCAGCGGGCGCGGCTTCGCGTTGCGCTGA
TGGAGGGCAAACAATCCGGTGACGCCGGTCCGCTTGACATGGATGAGATCAAGCGCGACGCGCGGAGCCGCTCTGGCGCT
TCTGATGCGTGA
ATGGCAAGCACAAGCGTCACACTTGGCCCCCATTGGGACGAATTCATCGCCCTGATGCTTAAAGAGGGGCGTTACGGGTC
AACCAGCGAGTTGATCCGCGCCTCTCTGCGCCTGATGGAGGAGCAGGAAGGTCAGCGGGCGCGGCTTCGCGTTGCGCTGA
TGGAGGGCAAACAATCCGGTGACGCCGGTCCGCTTGACATGGATGAGATCAAGCGCGACGCGCGGAGCCGCTCTGGCGCT
TCTGATGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A387K1G3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A387K023 |