Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1878642..1879262 Replicon chromosome
Accession NZ_CP049290
Organism Enterobacter hormaechei subsp. steigerwaltii strain 08-175

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag G6324_RS09100 Protein ID WP_015571250.1
Coordinates 1878642..1878860 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag G6324_RS09105 Protein ID WP_006809850.1
Coordinates 1878888..1879262 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6324_RS09070 (G6324_09065) 1874654..1874914 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
G6324_RS09075 (G6324_09070) 1874917..1875057 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
G6324_RS09080 (G6324_09075) 1875054..1875764 - 711 WP_023303201.1 GNAT family protein -
G6324_RS09085 (G6324_09080) 1875866..1877326 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
G6324_RS09090 (G6324_09085) 1877298..1877765 - 468 WP_017383209.1 YlaC family protein -
G6324_RS09095 (G6324_09090) 1877882..1878433 - 552 WP_023303203.1 maltose O-acetyltransferase -
G6324_RS09100 (G6324_09095) 1878642..1878860 - 219 WP_015571250.1 HHA domain-containing protein Toxin
G6324_RS09105 (G6324_09100) 1878888..1879262 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
G6324_RS09110 (G6324_09105) 1879773..1882919 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
G6324_RS09115 (G6324_09110) 1882942..1884135 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T151175 WP_015571250.1 NZ_CP049290:c1878860-1878642 [Enterobacter hormaechei subsp. steigerwaltii]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T151175 NZ_CP065354:c2054070-2053708 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT151175 WP_006809850.1 NZ_CP049290:c1879262-1878888 [Enterobacter hormaechei subsp. steigerwaltii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT151175 NZ_CP065354:c2054237-2054067 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References