Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 120777..121302 | Replicon | plasmid p602068_185 |
| Accession | NZ_CP049286 | ||
| Organism | Shigella boydii strain 602068 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | Q326Z8 |
| Locus tag | G5S54_RS23785 | Protein ID | WP_001159860.1 |
| Coordinates | 120777..121082 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | Q7BEK0 |
| Locus tag | G5S54_RS23790 | Protein ID | WP_000813626.1 |
| Coordinates | 121084..121302 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G5S54_RS23750 | 115811..116653 | - | 843 | WP_000931198.1 | polysaccharide deacetylase family protein | - |
| G5S54_RS23755 | 117017..117133 | - | 117 | WP_004996477.1 | hypothetical protein | - |
| G5S54_RS23760 | 117340..118037 | + | 698 | Protein_138 | IS1 family transposase | - |
| G5S54_RS23765 | 118101..118273 | - | 173 | Protein_139 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| G5S54_RS23770 | 118270..118539 | - | 270 | WP_000079956.1 | hypothetical protein | - |
| G5S54_RS23775 | 118747..120384 | - | 1638 | WP_039060807.1 | T3SS effector E3 ubiquitin-protein ligase IpaH9.8 | - |
| G5S54_RS23780 | 120646..120753 | - | 108 | WP_023592908.1 | transposase domain-containing protein | - |
| G5S54_RS23785 | 120777..121082 | - | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| G5S54_RS23790 | 121084..121302 | - | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| G5S54_RS23800 | 123241..123537 | + | 297 | WP_072072579.1 | transposase | - |
| G5S54_RS23805 | 123534..123884 | + | 351 | WP_000624671.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| G5S54_RS23810 | 123915..125507 | + | 1593 | WP_001072385.1 | IS66 family transposase | - |
| G5S54_RS23815 | 125733..125852 | + | 120 | Protein_149 | transposase domain-containing protein | - |
| G5S54_RS23820 | 125892..126152 | - | 261 | Protein_150 | IS1 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ospC3 / ospI / ospE2 / senB / ospC1 / ospD3/senA / ipaH7.8 / ipaH4.5 / ipaH1.4 / ipgB2 / ospD1 / ospF / ospD2 / ospC4 / ospC4 / ospB / icsP/sopA / nleE / ospC2 / ipaH9.8 / papC / icsA/virG / virA / spa40 / spa29 / spa9 / spa24 / spa33 / spa32 / spa13 / spa47 / spa15 / mxiA / mxiC / mxiD / mxiE / mxiM / mxiL / mxiN / mxiK / mxiJ / mxiI / mxiH / mxiG / ipgF / ipgE / ipgD / icsB / ipgA / ipgB1 / ipgC / ipaB / ipaC / ipaD / ipaA / ipaA / ipaJ | 1..185316 | 185316 | |
| - | inside | IScluster/Tn | - | ipaH9.8 | 111412..130928 | 19516 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11736.59 Da Isoelectric Point: 6.4674
>T151171 WP_001159860.1 NZ_CP049286:c121082-120777 [Shigella boydii]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T151171 NZ_CP065353:c2453922-2453656 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8333.36 Da Isoelectric Point: 6.2838
>AT151171 WP_000813626.1 NZ_CP049286:c121302-121084 [Shigella boydii]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW
Download Length: 219 bp
>AT151171 NZ_CP065353:c2454179-2453922 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P7TTN3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7BEK0 |