Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4109737..4110368 Replicon chromosome
Accession NZ_CP049285
Organism Shigella boydii strain 602068

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag G5S54_RS20895 Protein ID WP_001259385.1
Coordinates 4110093..4110368 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag G5S54_RS20890 Protein ID WP_000593554.1
Coordinates 4109737..4110096 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S54_RS20865 4105869..4106813 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
G5S54_RS20870 4106810..4107643 + 834 WP_001008950.1 nickel ABC transporter permease subunit NikC -
G5S54_RS20875 4107643..4108407 + 765 WP_001136224.1 nickel import ATP-binding protein NikD -
G5S54_RS20880 4108404..4109210 + 807 WP_000173706.1 nickel import ATP-binding protein NikE -
G5S54_RS20885 4109216..4109617 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
G5S54_RS20890 4109737..4110096 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G5S54_RS20895 4110093..4110368 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
G5S54_RS20900 4110441..4111565 - 1125 WP_001216257.1 ABC transporter permease -
G5S54_RS20905 4111565..4114300 - 2736 WP_000149139.1 ribosome-associated ATPase/putative transporter RbbA -
G5S54_RS20910 4114297..4115364 - 1068 WP_000361467.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T151167 WP_001259385.1 NZ_CP049285:c4110368-4110093 [Shigella boydii]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T151167 NZ_CP065353:c1850000-1849848 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT151167 WP_000593554.1 NZ_CP049285:c4110096-4109737 [Shigella boydii]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT151167 NZ_CP065353:c1850624-1850025 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCTGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References