Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 199358..199883 | Replicon | plasmid p600657_208 |
| Accession | NZ_CP049282 | ||
| Organism | Shigella boydii strain 600657 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | Q326Z8 |
| Locus tag | G5S55_RS24810 | Protein ID | WP_001159860.1 |
| Coordinates | 199578..199883 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | Q7BEK0 |
| Locus tag | G5S55_RS24805 | Protein ID | WP_000813626.1 |
| Coordinates | 199358..199576 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G5S55_RS24780 | 195099..195848 | - | 750 | WP_000828661.1 | phosphatase PAP2 family protein | - |
| G5S55_RS24785 | 196211..196444 | + | 234 | Protein_232 | DDE-type integrase/transposase/recombinase | - |
| G5S55_RS24790 | 196457..197149 | + | 693 | Protein_233 | group II intron reverse transcriptase/maturase | - |
| G5S55_RS24795 | 197204..198417 | + | 1214 | WP_167692677.1 | IS3 family transposase | - |
| G5S55_RS24800 | 198493..198765 | - | 273 | WP_012421738.1 | hypothetical protein | - |
| G5S55_RS24805 | 199358..199576 | + | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| G5S55_RS24810 | 199578..199883 | + | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| G5S55_RS24815 | 199919..200014 | + | 96 | Protein_238 | transposase domain-containing protein | - |
| G5S55_RS24820 | 200276..201913 | + | 1638 | WP_012421769.1 | T3SS effector E3 ubiquitin-protein ligase IpaH9.8 | - |
| G5S55_RS24825 | 202121..202390 | + | 270 | WP_000079956.1 | hypothetical protein | - |
| G5S55_RS24830 | 202387..202613 | + | 227 | Protein_241 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| G5S55_RS24835 | 202642..203127 | + | 486 | WP_039058926.1 | protein kinase | - |
| G5S55_RS24840 | 203142..203839 | - | 698 | Protein_243 | IS1 family transposase | - |
| G5S55_RS24845 | 204046..204162 | + | 117 | WP_004996477.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ospC2 / nleE / icsP/sopA / ospB / ospC4 / ospD2 / ospF / ospD1 / ipgB2 / ospI / ipaH1.4 / ospE2 / ospD3/senA / ospC1 / senB / ipaH7.8 / ipaH4.5 / ospC3 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / papC / ipaH9.8 / ospG | 1..208836 | 208836 | |
| - | inside | IScluster/Tn | - | ipaH9.8 / ospG | 180028..203645 | 23617 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11736.59 Da Isoelectric Point: 6.4674
>T151153 WP_001159860.1 NZ_CP049282:199578-199883 [Shigella boydii]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T151153 NZ_CP065349:59959-60264 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGGCGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTCTCCCGTGAGCTCTATCCGGTGG
TGCACATCGGGGACGAGAGCTGGCGCCTGATGACCACGGACATGGCCAGCGTCCCGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCCGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGGCGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTCTCCCGTGAGCTCTATCCGGTGG
TGCACATCGGGGACGAGAGCTGGCGCCTGATGACCACGGACATGGCCAGCGTCCCGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCCGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8333.36 Da Isoelectric Point: 6.2838
>AT151153 WP_000813626.1 NZ_CP049282:199358-199576 [Shigella boydii]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW
Download Length: 219 bp
>AT151153 NZ_CP065349:59739-59957 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGCTACTGAAATCCGCGGACGTCAATATATCCGGTCT
GGTGAACACGGCCATGCAGAATGAGGCCCGCCGTTTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGGTTTATTGAAATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGCTACTGAAATCCGCGGACGTCAATATATCCGGTCT
GGTGAACACGGCCATGCAGAATGAGGCCCGCCGTTTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGGTTTATTGAAATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P7TTN3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7BEK0 |