Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3605947..3606601 Replicon chromosome
Accession NZ_CP049281
Organism Shigella boydii strain 600657

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag G5S55_RS18635 Protein ID WP_000244777.1
Coordinates 3605947..3606354 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2S8DWY8
Locus tag G5S55_RS18640 Protein ID WP_039059554.1
Coordinates 3606335..3606601 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S55_RS18615 3601904..3603637 - 1734 WP_000813182.1 single-stranded-DNA-specific exonuclease RecJ -
G5S55_RS18620 3603643..3604353 - 711 WP_000715205.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G5S55_RS18625 3604378..3605274 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G5S55_RS18630 3605386..3605907 + 522 WP_001055874.1 flavodoxin FldB -
G5S55_RS18635 3605947..3606354 - 408 WP_000244777.1 toxin CptA Toxin
G5S55_RS18640 3606335..3606601 - 267 WP_039059554.1 FAD assembly factor SdhE Antitoxin
G5S55_RS18645 3606844..3607824 + 981 WP_000886098.1 tRNA-modifying protein YgfZ -
G5S55_RS18650 3608020..3608679 - 660 WP_000250274.1 hemolysin III family protein -
G5S55_RS18655 3608843..3609154 - 312 WP_001182969.1 N(4)-acetylcytidine aminohydrolase -
G5S55_RS18660 3609199..3610632 + 1434 WP_024258645.1 6-phospho-beta-glucosidase BglA -
G5S55_RS18665 3610689..3611432 - 744 WP_000951947.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T151148 WP_000244777.1 NZ_CP049281:c3606354-3605947 [Shigella boydii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T151148 NZ_CP065347:c3393206-3393104 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10577.15 Da        Isoelectric Point: 4.8727

>AT151148 WP_039059554.1 NZ_CP049281:c3606601-3606335 [Shigella boydii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
WERGPVAI

Download         Length: 267 bp

>AT151148 NZ_CP065347:3393097-3393242 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8DWY8

References