Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/ElaA-DUF1778 |
| Location | 61125..61882 | Replicon | plasmid p600690_216 |
| Accession | NZ_CP049279 | ||
| Organism | Shigella boydii strain 600690 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q31SN7 |
| Locus tag | G5S56_RS23965 | Protein ID | WP_000501969.1 |
| Coordinates | 61397..61882 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | Q31SN8 |
| Locus tag | G5S56_RS23960 | Protein ID | WP_011114751.1 |
| Coordinates | 61125..61409 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G5S56_RS23930 (G5S56_23930) | 56195..56869 | + | 675 | WP_004967157.1 | IS66-like element accessory protein TnpA | - |
| G5S56_RS23935 (G5S56_23935) | 56866..57213 | + | 348 | WP_000631709.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| G5S56_RS23940 (G5S56_23940) | 57233..57931 | + | 699 | Protein_62 | IS66-like element ISSfl3 family transposase | - |
| G5S56_RS23945 (G5S56_23945) | 57996..59152 | + | 1157 | WP_086020934.1 | IS3-like element IS600 family transposase | - |
| G5S56_RS23950 (G5S56_23950) | 59194..59805 | + | 612 | Protein_64 | IS66 family transposase | - |
| G5S56_RS23955 (G5S56_23955) | 60059..60223 | - | 165 | WP_001346193.1 | hypothetical protein | - |
| G5S56_RS23960 (G5S56_23960) | 61125..61409 | + | 285 | WP_011114751.1 | DUF1778 domain-containing protein | Antitoxin |
| G5S56_RS23965 (G5S56_23965) | 61397..61882 | + | 486 | WP_000501969.1 | GNAT family N-acetyltransferase | Toxin |
| G5S56_RS23970 (G5S56_23970) | 62055..62387 | - | 333 | Protein_68 | IS4/IS5 family transposase | - |
| G5S56_RS23975 (G5S56_23975) | 62450..62602 | + | 153 | Protein_69 | transposase | - |
| G5S56_RS23980 (G5S56_23980) | 62667..63823 | + | 1157 | WP_085948186.1 | IS3-like element IS600 family transposase | - |
| G5S56_RS23990 (G5S56_23990) | 63867..64873 | + | 1007 | Protein_71 | IS3-like element IS600 family transposase | - |
| G5S56_RS23995 (G5S56_23995) | 64912..65052 | - | 141 | Protein_72 | IS3 family transposase | - |
| G5S56_RS24000 (G5S56_24000) | 65122..66309 | - | 1188 | WP_178966726.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | virA / spa40 / spa29 / spa9 / spa24 / spa33 / spa32 / spa13 / spa47 / spa15 / mxiA / mxiC / mxiD / mxiE / mxiM / mxiL / mxiN / mxiK / mxiJ / mxiI / mxiH / mxiG / ipgF / ipgE / ipgD / icsB / ipgA / ipgB1 / ipgC / ipaB / ipaC / ipaD / ipaA / ipaJ / ospC3 / ospD3/senA / ospC1 / faeI / faeH / faeF / faeE / faeD / faeC / ospE2 / ospE2 / ipaH1.4 / ipaH7.8 / ipaH4.5 / ipgB2 / ospD1 / ospF / ospD2 / ospC2 / ospC4 / ospC4 / ospC3 / ospB / icsP/sopA / nleE / ospC2 / ospG / ipaH9.8 / ospI / papC | 1..216073 | 216073 | |
| - | inside | IScluster/Tn | - | ospC3 / ospD3/senA / ospC1 | 48315..73457 | 25142 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17712.54 Da Isoelectric Point: 10.1083
>T151128 WP_000501969.1 NZ_CP049279:61397-61882 [Shigella boydii]
MGCVTAPEPLSSFHQVAEFVSGEAVLDDWLKQKGLKNQAIGATRTFVVCRKGTQQIVGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVRRCYRVAENIGVRAIMVHALTENAKQFYIHHGFKPSKTQVQTLFLKLP
Q
MGCVTAPEPLSSFHQVAEFVSGEAVLDDWLKQKGLKNQAIGATRTFVVCRKGTQQIVGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVRRCYRVAENIGVRAIMVHALTENAKQFYIHHGFKPSKTQVQTLFLKLP
Q
Download Length: 486 bp
>T151128 NZ_CP065342:c8097-7792 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAAAGCCGCTACCGTCTGTTCGTCGACGTGCAGAGTGACATTATTGACAC
CCCGGGACGCCGGATGGTGATCCCGCTGGTCAGCGCCCGCCTGCTGTCCGACAAAGTCTCGCGTGAGCTTTATCCGGTGG
TGTCAGTCGGAGGTGACCCTTATCGTCTGATGACCACGGATATGGCCAGTGTGCCGGCCACTGTCATCGGGGAAGAAGTG
GCCGATCTCAGCCACCTGGAGAATGACATCCAGAACGCCATCAACCTGATGTTCCGGGGGATCTGA
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAAAGCCGCTACCGTCTGTTCGTCGACGTGCAGAGTGACATTATTGACAC
CCCGGGACGCCGGATGGTGATCCCGCTGGTCAGCGCCCGCCTGCTGTCCGACAAAGTCTCGCGTGAGCTTTATCCGGTGG
TGTCAGTCGGAGGTGACCCTTATCGTCTGATGACCACGGATATGGCCAGTGTGCCGGCCACTGTCATCGGGGAAGAAGTG
GCCGATCTCAGCCACCTGGAGAATGACATCCAGAACGCCATCAACCTGATGTTCCGGGGGATCTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10871.52 Da Isoelectric Point: 4.6812
>AT151128 WP_011114751.1 NZ_CP049279:61125-61409 [Shigella boydii]
MIYGGFMKSGVQLNLRARESQRILIDAAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDRQYEEFIEMLDAPVADDP
AIEKLLARKPQWDV
MIYGGFMKSGVQLNLRARESQRILIDAAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDRQYEEFIEMLDAPVADDP
AIEKLLARKPQWDV
Download Length: 285 bp
>AT151128 NZ_CP065342:c8317-8099 [Klebsiella pneumoniae]
GTGAAGCAGCGTATTACAGTGACAGTGGACAGCGACAGCTATCAGTTGCTCAAGGCATACGACGTAAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGCGCCGAACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATCGAGGCTAACGGATCGTTTGCTGACGAAAACAGGGATTGGTGA
GTGAAGCAGCGTATTACAGTGACAGTGGACAGCGACAGCTATCAGTTGCTCAAGGCATACGACGTAAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGCGCCGAACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATCGAGGCTAACGGATCGTTTGCTGACGAAAACAGGGATTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q31SN7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4V1CUJ1 |