Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2645927..2646565 Replicon chromosome
Accession NZ_CP049278
Organism Shigella boydii strain 600690

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G5S56_RS13080 Protein ID WP_078166743.1
Coordinates 2646389..2646565 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G5S56_RS13075 Protein ID WP_001270286.1
Coordinates 2645927..2646343 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S56_RS13055 (2641081) 2641081..2642020 - 940 Protein_2561 ABC transporter permease -
G5S56_RS13060 (2642021) 2642021..2643034 - 1014 WP_078166745.1 ABC transporter ATP-binding protein -
G5S56_RS13065 (2643052) 2643052..2644197 - 1146 WP_078166744.1 ABC transporter substrate-binding protein -
G5S56_RS13070 (2644442) 2644442..2645848 - 1407 WP_001543733.1 PLP-dependent aminotransferase family protein -
G5S56_RS13075 (2645927) 2645927..2646343 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
G5S56_RS13080 (2646389) 2646389..2646565 - 177 WP_078166743.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
G5S56_RS13085 (2646787) 2646787..2647017 + 231 WP_000494244.1 YncJ family protein -
G5S56_RS13090 (2647109) 2647109..2649070 - 1962 WP_047085199.1 23S rRNA 5-hydroxycytidine C2501 synthase -
G5S56_RS13095 (2649143) 2649143..2649679 - 537 WP_078166742.1 DNA-binding transcriptional regulator SutR -
G5S56_RS13100 (2649771) 2649771..2650943 + 1173 WP_284522428.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6765.87 Da        Isoelectric Point: 11.2298

>T151122 WP_078166743.1 NZ_CP049278:c2646565-2646389 [Shigella boydii]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHLCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T151122 NZ_CP065341:1931065-1931167 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT151122 WP_001270286.1 NZ_CP049278:c2646343-2645927 [Shigella boydii]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT151122 NZ_CP065341:c1931174-1931029 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References