Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2624376..2624902 Replicon chromosome
Accession NZ_CP049278
Organism Shigella boydii strain 600690

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag G5S56_RS12960 Protein ID WP_000323025.1
Coordinates 2624376..2624663 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag G5S56_RS12965 Protein ID WP_000534858.1
Coordinates 2624663..2624902 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S56_RS12930 (2621084) 2621084..2621905 - 822 WP_078167389.1 antitermination protein -
G5S56_RS12935 (2621920) 2621920..2622277 - 358 Protein_2536 RusA family crossover junction endodeoxyribonuclease -
G5S56_RS12940 (2622290) 2622290..2623333 - 1044 WP_078167390.1 DUF968 domain-containing protein -
G5S56_RS12945 (2623335) 2623335..2623613 - 279 WP_024258459.1 hypothetical protein -
G5S56_RS12950 (2623680) 2623680..2623931 - 252 WP_000980987.1 protein Rem -
G5S56_RS12955 (2624149) 2624149..2624304 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
G5S56_RS12960 (2624376) 2624376..2624663 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
G5S56_RS12965 (2624663) 2624663..2624902 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
G5S56_RS25275 (2624927) 2624927..2625052 + 126 Protein_2543 protein YdfV -
G5S56_RS12970 (2625118) 2625118..2626274 + 1157 WP_178966658.1 IS3-like element IS600 family transposase -
G5S56_RS12975 (2626319) 2626319..2626633 - 315 Protein_2545 hypothetical protein -
G5S56_RS12980 (2627419) 2627419..2627631 - 213 WP_000882238.1 DUF5445 family protein -
G5S56_RS25280 (2627707) 2627707..2628324 - 618 Protein_2547 glutathione S-transferase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2596324..2626274 29950
- inside IScluster/Tn - - 2596324..2626274 29950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T151121 WP_000323025.1 NZ_CP049278:c2624663-2624376 [Shigella boydii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T151121 NZ_CP065341:1498649-1499131 [Klebsiella pneumoniae]
GTGGGACGTGTAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTTGA
TGAATGGCTAAAGCACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAACTACAGGCAGACTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCCGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT151121 WP_000534858.1 NZ_CP049278:c2624902-2624663 [Shigella boydii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT151121 NZ_CP065341:1498395-1498661 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References