Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1331541..1332159 Replicon chromosome
Accession NZ_CP049278
Organism Shigella boydii strain 600690

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G5S56_RS06375 Protein ID WP_001291435.1
Coordinates 1331541..1331759 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag G5S56_RS06380 Protein ID WP_000344800.1
Coordinates 1331785..1332159 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S56_RS06345 (1326840) 1326840..1327067 + 228 WP_000513895.1 DUF2188 domain-containing protein -
G5S56_RS25075 (1327268) 1327268..1327549 + 282 WP_000566734.1 hypothetical protein -
G5S56_RS06355 (1328124) 1328124..1328477 + 354 WP_000878140.1 DUF1428 domain-containing protein -
G5S56_RS06360 (1328519) 1328519..1330069 - 1551 WP_078167394.1 cyclic-guanylate-specific phosphodiesterase PdeB -
G5S56_RS06365 (1330233) 1330233..1330703 - 471 WP_000136192.1 YlaC family protein -
G5S56_RS06370 (1330819) 1330819..1331370 - 552 WP_000102564.1 maltose O-acetyltransferase -
G5S56_RS06375 (1331541) 1331541..1331759 - 219 WP_001291435.1 HHA domain-containing protein Toxin
G5S56_RS06380 (1331785) 1331785..1332159 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
G5S56_RS06385 (1332705) 1332705..1335854 - 3150 WP_078167514.1 efflux RND transporter permease AcrB -
G5S56_RS06390 (1335877) 1335877..1337070 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151110 WP_001291435.1 NZ_CP049278:c1331759-1331541 [Shigella boydii]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T151110 NZ_CP065261:c2419601-2419233 [Streptomyces clavuligerus]
ATGCACTACCTCACCCTGCCCGAGCTGCTGAACCTCGCGGAGCGGCTGCGGGCGGCCGAGGTGCGCGACTACGGTCTGCT
GGACTCCGCCCTCGCGCGCCCCCAGGCGAGCGTCTTCGGCCAGGACGCCTACCCGGATGTCTGGCAGAAGGCCGCCGCCC
TGATGGAGTCCCTGGCCCGCAACCACGGACTGGTCGACGGCAACAAGCGGATCGCCTGGTATGCCACCTGGGTCTTTCTC
CATGTGAACGGCCATCCGCTGGACCCGGAATTCGACGTGGACGAGGCGGAACGGTTTGTTCTGGACGTCTGCCAGGGGGC
ACTCGACGTCCCCAAGATCGCGTCGGGGCTGCTGCGCTTCGCCCGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT151110 WP_000344800.1 NZ_CP049278:c1332159-1331785 [Shigella boydii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT151110 NZ_CP065261:c2419798-2419601 [Streptomyces clavuligerus]
ATGGCTGGTCTCAATGTGCGATTCACCGAGGAAGAGCTCACCGCCCTGCGGGAGCGGGCCGAAGCGGAGGGCCGCAGTAT
GCAGTCCTTCGCGCACGACGCGGTGATCAGAGCGATCAACGAACGCGCGCGGCTGTTCAACGAGGCCGCCGAGCATGTGC
TGAGGGCGAGCGAGGAGCTGAACCGGAGGCTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References