Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 940673..941223 Replicon chromosome
Accession NZ_CP049278
Organism Shigella boydii strain 600690

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag G5S56_RS04490 Protein ID WP_001160972.1
Coordinates 940909..941223 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag G5S56_RS04485 Protein ID WP_000125567.1
Coordinates 940673..940906 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S56_RS04460 (935822) 935822..936109 + 288 WP_000203729.1 ferredoxin-like protein FixX -
G5S56_RS04465 (936168) 936168..937499 + 1332 WP_078166228.1 MFS transporter -
G5S56_RS04470 (937610) 937610..938140 + 531 WP_000600743.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
G5S56_RS04475 (938133) 938133..939917 + 1785 WP_078166227.1 glutathione-regulated potassium-efflux system protein KefC -
G5S56_RS04480 (940108) 940108..940587 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
G5S56_RS04485 (940673) 940673..940906 + 234 WP_000125567.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
G5S56_RS04490 (940909) 940909..941223 + 315 WP_001160972.1 CcdB family protein Toxin
G5S56_RS04495 (941220) 941220..942068 - 849 WP_000257196.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
G5S56_RS04500 (942075) 942075..942452 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
G5S56_RS04505 (942455) 942455..943276 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
G5S56_RS04510 (943273) 943273..944262 - 990 WP_000241259.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
G5S56_RS04515 (944262) 944262..945548 - 1287 WP_078166226.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11801.86 Da        Isoelectric Point: 9.0851

>T151105 WP_001160972.1 NZ_CP049278:940909-941223 [Shigella boydii]
MQFTVYRSRSRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASTHRMLIKGALDFMLDGI

Download         Length: 315 bp

>T151105 NZ_CP065246:4449438-4449806 [Streptomyces clavuligerus]
ATGCACTACCTCACCCTGCCCGAGCTGCTGAACCTCGCGGAGCGGCTGCGGGCGGCCGAGGTGCGCGACTACGGTCTGCT
GGACTCCGCCCTCGCGCGCCCCCAGGCGAGCGTCTTCGGCCAGGACGCCTACCCGGATGTCTGGCAGAAGGCCGCCGCCC
TGATGGAGTCCCTGGCCCGCAACCACGGACTGGTCGACGGCAACAAGCGGATCGCCTGGTATGCCACCTGGGTCTTTCTC
CATGTGAACGGCCATCCGCTGGACCCGGAATTCGACGTGGACGAGGCGGAACGGTTTGTTCTGGACGTCTGCCAGGGGGC
ACTCGACGTCCCCAAGATCGCGTCGGGGCTGCTGCGCTTCGCCCGCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8544.55 Da        Isoelectric Point: 5.8147

>AT151105 WP_000125567.1 NZ_CP049278:940673-940906 [Shigella boydii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSEEYRSF

Download         Length: 234 bp

>AT151105 NZ_CP065246:4449241-4449438 [Streptomyces clavuligerus]
ATGGCTGGTCTCAATGTGCGATTCACCGAGGAAGAGCTCACCGCCCTGCGGGAGCGGGCCGAAGCGGAGGGCCGCAGTAT
GCAGTCCTTCGCGCACGACGCGGTGATCAGAGCGATCAACGAACGCGCGCGGCTGTTCAACGAGGCCGCCGAGCATGTGC
TGAGGGCGAGCGAGGAGCTGAACCGGAGGCTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References