Detailed information of TA system TA151100

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 62671..63199
• Replicon: chromosome
• Accession: NZ_CP049274
• Organism: Campylobacter concisus strain P10CDO-S2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U2FZT6
• Locus tag: CVT06_RS00270
• Protein ID: WP_021084979.1
• Coordinates: 62671..62958 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CVT06_RS00275
• Protein ID: WP_103604484.1
• Coordinates: 62948..63199 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVT06_RS00245	57818..58481	+	664	Protein_46	replisome organizer	-
CVT06_RS00250	58589..59426	+	838	Protein_47	ATP-binding protein	-
CVT06_RS00255	59488..59661	+	174	WP_009295461.1	transposon-encoded TnpW family protein	-
CVT06_RS00260	60334..61929	-	1596	WP_196380748.1	relaxase/mobilization nuclease domain-containing protein	-
CVT06_RS00265	61977..62306	-	330	WP_196380749.1	hypothetical protein	-
CVT06_RS00270	62671..62958	-	288	WP_021084979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CVT06_RS00275	62948..63199	-	252	WP_103604484.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CVT06_RS00280	63282..65054	-	1773	WP_196380771.1	site-specific integrase	-
CVT06_RS00285	65843..66544	+	702	WP_009294402.1	IS1595-like element ISCamsp1 family transposase	-
CVT06_RS00290	67189..67491	+	303	WP_087584838.1	hypothetical protein	-
CVT06_RS00295	67469..68014	+	546	WP_107793893.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	33692..105936	72244
	-	flank	IS/Tn	-	-	65843..66544	701

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11387.25 Da
• Isoelectric Point: 9.5216

>T151100 WP_021084979.1 NZ_CP049274:c62958-62671 [Campylobacter concisus]
MSYELEFLPSALKEWQKLDNSIKVQFKKKLSERLENPKVTKDKLRGYEDVYKIKLRDVGYRLAYQVKDDEIVVLVLVVGK
RENNEVYEMLKDKFN

Nucleotide

• Length: 288 bp

>T151100 NZ_CP065233:c3983791-3983489 [Alteromonas sp. B31-7]
GTGAAACCATTTAAGTTAACTGTACTCGCAAAATCCGATTTAAAAGATATCACGTTATTTACGCAACGGAAATGGGGACG
GGAACAGCGTAATGTGTACCTAAAACAGTTCGACGATTCATTTTGGATGTTGTCTGAAAATCCTGTTATCGGTAAAAGCT
GCGACGACATAAGAGACGGATACAGAAAGTTTCCGCAAGGTAGTCACGTTATTTTCTACAAGCAAACTGGTAGCCAGGAA
ATTCTGATTATAAGAATTCTTCATAAAAGTATGGATGTAAATCCATTACGCTTTGGCGCATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9014.31 Da
• Isoelectric Point: 4.9901

>AT151100 WP_103604484.1 NZ_CP049274:c63199-62948 [Campylobacter concisus]
MQTIQANFTASISELKKSPAQILKQAGDNVVAILNHNVPSAYLVPSSVYEKMTEIIEEYHLSKAVDATLASGEKPVKVSL
DEL

Nucleotide

• Length: 252 bp

>AT151100 NZ_CP065233:c3984030-3983788 [Alteromonas sp. B31-7]
ATGGCTAAAAATACCAGCATTACCCTTGGTGACCATTTTGATGGCTTTATTGCTCGCCAAATTCAAACTGGTCGATATGG
TTCAGCGAGCGAAGTAATTCGGTCAGCTCTTCGCTTGCTAGAAACACAGGAGACCAAATTAAACACTTTGCGTCAATTAC
TTGTAGCAGGTGAAGAAAGCGGCGAGGCTGAATACGACCTTGAGAACTTGATATCAGAACTAGATGGTGAATTAAAAGAG
TGA

Structures

Toxin

• AlphaFold DB: U2FZT6