Detailed information of TA system TA151096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1690002..1690530
• Replicon: chromosome
• Accession: NZ_CP049266
• Organism: Campylobacter concisus strain P1CDO3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M5IRL2
• Locus tag: CVT01_RS08300
• Protein ID: WP_009295458.1
• Coordinates: 1690002..1690289 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M5IPY6
• Locus tag: CVT01_RS08305
• Protein ID: WP_009295321.1
• Coordinates: 1690279..1690530 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVT01_RS08275	1685155..1685818	+	664	Protein_1607	replisome organizer	-
CVT01_RS08280	1685926..1686763	+	838	Protein_1608	ATP-binding protein	-
CVT01_RS08285	1686825..1686998	+	174	WP_009295461.1	transposon-encoded TnpW family protein	-
CVT01_RS08290	1687666..1689258	-	1593	WP_107714714.1	relaxase/mobilization nuclease domain-containing protein	-
CVT01_RS08295	1689294..1689635	-	342	WP_107714713.1	hypothetical protein	-
CVT01_RS08300	1690002..1690289	-	288	WP_009295458.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CVT01_RS08305	1690279..1690530	-	252	WP_009295321.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CVT01_RS08310	1690613..1692385	-	1773	WP_107714712.1	site-specific integrase	-
CVT01_RS08315	1693160..1693924	-	765	WP_107714711.1	DUF996 domain-containing protein	-
CVT01_RS08320	1694471..1694614	-	144	Protein_1616	antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11299.19 Da
• Isoelectric Point: 9.7349

>T151096 WP_009295458.1 NZ_CP049266:c1690289-1690002 [Campylobacter concisus]
MSYELEFLPGALKEWQKLDNSIKVQFKKKLSERLENPKVAKDKLRGYEDVYKIKLRDVGYRLAYQVKDSEIVVLVLVVGK
RENNEVYEMLKDKFN

Nucleotide

• Length: 288 bp

>T151096 NZ_CP065233:2896530-2896847 [Alteromonas sp. B31-7]
ATGATTTTTATCGAAACTAGCCTTTTCACCAAACTGCTACCTAGTTACTTAGGCGATGATGATTATCGAGGCCTACAAAA
TTATCTTTTACAACACCCAGAATCTGGTGATGTTGTGAGAGGCTCTGGAGGCGTTAGAAAAGTGCGTTGGGCAGCCGACG
GACAAGGGAAAAGTGGCGGTGTTAGGGTTATTTATTACTGGAAAAAATCCGATGATGAAGTGTGGATGTTGACCATATAC
GGTAAATCGGACAAAGCAACCATACCTGGTCATCAACTTAAAAAGATCGCGGAGGCTATTAATAATGACAAATCGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8938.26 Da
• Isoelectric Point: 4.9901

>AT151096 WP_009295321.1 NZ_CP049266:c1690530-1690279 [Campylobacter concisus]
MQTIQANFTASISELKKSPAQILKQAGDNVVAILNHNVPSAYLVPSAVYEKMAEIIEEYHLSKAVDAALASGEKPVKVSL
DEL

Nucleotide

• Length: 252 bp

>AT151096 NZ_CP065233:2896834-2897121 [Alteromonas sp. B31-7]
ATGACAAATCGTGATTTAGGTGCCGAAATTCTTGCGGGCATTGAAGAAATTCAGAGCTTTAAGAAAGGAGAAGTAGAACT
AAAAACTACGCAACTTTCAGAGCCATCATCGCCTGATGTTATTAGGGCAAAACTTAGAATGTCTCAGGCGGCATTCGCAG
CCATGCTCGGAGTCAGTAAGCGAACATTGCAAGACTGGGAACAAGGTCGTCGTGAACCAAATGGCCCTGCTATTGCATTA
TTGAGAATCGCTGAACAACACCCAGAAGTATTCTCAGACTTACACTAA

Structures

Toxin

• AlphaFold DB: M5IRL2

Antitoxin

• AlphaFold DB: M5IPY6