Detailed information of TA system TA151095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1632601..1633129
• Replicon: chromosome
• Accession: NZ_CP049264
• Organism: Campylobacter concisus strain P11CDO-S1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M5IRL2
• Locus tag: CVT07_RS08105
• Protein ID: WP_009295458.1
• Coordinates: 1632601..1632888 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CVT07_RS08110
• Protein ID: WP_107937751.1
• Coordinates: 1632878..1633129 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVT07_RS08080	1627754..1628417	+	664	Protein_1569	replisome organizer	-
CVT07_RS08085	1628525..1629362	+	838	Protein_1570	ATP-binding protein	-
CVT07_RS08090	1629424..1629597	+	174	WP_009295461.1	transposon-encoded TnpW family protein	-
CVT07_RS08095	1630265..1631857	-	1593	WP_107937753.1	relaxase/mobilization nuclease domain-containing protein	-
CVT07_RS08100	1631893..1632234	-	342	WP_009295459.1	hypothetical protein	-
CVT07_RS08105	1632601..1632888	-	288	WP_009295458.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CVT07_RS08110	1632878..1633129	-	252	WP_107937751.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CVT07_RS08115	1633212..1634993	-	1782	WP_107937748.1	site-specific integrase	-
CVT07_RS08120	1635588..1635809	+	222	WP_107937746.1	hypothetical protein	-
CVT07_RS08125	1636397..1636669	+	273	WP_196375718.1	hypothetical protein	-
CVT07_RS08130	1636647..1637192	+	546	WP_196375719.1	hypothetical protein	-
CVT07_RS08135	1637345..1637707	+	363	WP_196375720.1	plasmid mobilization relaxosome protein MobC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1624384..1641668	17284

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11299.19 Da
• Isoelectric Point: 9.7349

>T151095 WP_009295458.1 NZ_CP049264:c1632888-1632601 [Campylobacter concisus]
MSYELEFLPGALKEWQKLDNSIKVQFKKKLSERLENPKVAKDKLRGYEDVYKIKLRDVGYRLAYQVKDSEIVVLVLVVGK
RENNEVYEMLKDKFN

Nucleotide

• Length: 288 bp

>T151095 NZ_CP065232:2568657-2568845 [Thalassospira sp. B30-1]
ATGGACAGCAAAACCATCCTGAAAAGGCTTCAGGCGGACGGTTGGGAAATCGTGCGCACGAAGGGCAGCCACCATCAATT
GAGCCACCCGACTAAGCCGGGGAAAGTGACGGTCCCGCATCCGAAACGTGATTTGCCGATTGGCACCGTCAAAAACATTG
AAAAGCAATCCGGCGTAAAGCTGCTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8956.28 Da
• Isoelectric Point: 4.9901

>AT151095 WP_107937751.1 NZ_CP049264:c1633129-1632878 [Campylobacter concisus]
MQTIQANFTASISELKKSPAQILKQAGDNVVAILNHNVPSAYLVPSAVYEKMAEIIEEYHLSKAVDVALASGEKSVKVSL
DEL

Nucleotide

• Length: 252 bp

>AT151095 NZ_CP065232:2568907-2569275 [Thalassospira sp. B30-1]
ATGAAACAGACCTATTGGGGTTTGGTCCACAAAGACGGCGGCAGCGATTTCGGAATTTCCTTTCCGGATTTTCCGGGCTG
CGTCAGTGCGGCATCATCCATGACCGAACTGGTGGAAATGGGCACCGAGGCCCTGACCCTGCATATCGATGGCATGCATG
AGGACGGCGAACCCATCCCCGCCCCGTCGCCGATGGTCGAACTGCCGAAAGACGCCGACGGGATCGTTGCGATTACCGTC
GCCGTGCCGGGCAAGAAACGCCGGATCAACCTGACCATTGACGCCAATCTGATTGACCAGATTGAAGCGAAGCACGGCAA
GGGGGCGGTTTCGGGGTTTCTGGAGGATGCGGCGCGGAAGGCGCTTTGA

Structures

Toxin

• AlphaFold DB: M5IRL2