Detailed information of TA system TA151094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 50530..51058
• Replicon: chromosome
• Accession: NZ_CP049263
• Organism: Campylobacter concisus strain H16O-S1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U2FZT6
• Locus tag: CVS89_RS00245
• Protein ID: WP_021084979.1
• Coordinates: 50530..50817 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CVS89_RS00250
• Protein ID: WP_084042015.1
• Coordinates: 50807..51058 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVS89_RS09870	45912..46256	+	345	WP_009295465.1	hypothetical protein	-
CVS89_RS00225	46454..47291	+	838	Protein_40	ATP-binding protein	-
CVS89_RS00230	47354..47527	+	174	WP_009295461.1	transposon-encoded TnpW family protein	-
CVS89_RS00235	48194..49786	-	1593	WP_103606168.1	relaxase/mobilization nuclease domain-containing protein	-
CVS89_RS00240	49834..50163	-	330	WP_103606169.1	hypothetical protein	-
CVS89_RS00245	50530..50817	-	288	WP_021084979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CVS89_RS00250	50807..51058	-	252	WP_084042015.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CVS89_RS00255	51140..52921	-	1782	WP_107848038.1	site-specific integrase	-
CVS89_RS00260	54228..54530	+	303	WP_035142770.1	hypothetical protein	-
CVS89_RS00265	54508..55053	+	546	WP_107848039.1	hypothetical protein	-
CVS89_RS00270	55206..55568	+	363	WP_084109992.1	plasmid mobilization relaxosome protein MobC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	30521..74421	43900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11387.25 Da
• Isoelectric Point: 9.5216

>T151094 WP_021084979.1 NZ_CP049263:c50817-50530 [Campylobacter concisus]
MSYELEFLPSALKEWQKLDNSIKVQFKKKLSERLENPKVTKDKLRGYEDVYKIKLRDVGYRLAYQVKDDEIVVLVLVVGK
RENNEVYEMLKDKFN

Nucleotide

• Length: 288 bp

>T151094 NZ_CP065232:c2449318-2449037 [Thalassospira sp. B30-1]
ATGAGGACGATTGAGTATTCGACCAGATTCAAGCGCGACTATAAACGTGAGGCAAAGGGCCGTTTTCGATCAGATATTGA
TGCGATCCTGATGCCGGTTCTTGAGGACCTTGTCGCGGACAAACCGCTGGATGCGCAATATCATGATCACGATCTTTCAG
GGAACTGGCGCGGCTACCGGGAATGCCACCTGAAGCCCGATCTGCTGCTGATCCACCGGAAAGACGGGGCCGACATCCTC
AGGCTTGCCCGCCTTGGATCGCATAGCGAATTGTTTAGCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8954.26 Da
• Isoelectric Point: 4.9901

>AT151094 WP_084042015.1 NZ_CP049263:c51058-50807 [Campylobacter concisus]
MQTIQANFTASISELKKSPAQILKQAGDNVVAILNHNVPSAYLVPSSVYEKMAEIIEEYHLSKAVDAALASGEKPVKVSL
DEL

Nucleotide

• Length: 252 bp

>AT151094 NZ_CP065232:c2449571-2449305 [Thalassospira sp. B30-1]
ATGTCCGCCACCGAAACCTATGTCCGGGCAAGAATTGACAGCGGCACGAAAATGCGGGCAACCAGCGCGCTTGATGCGAT
GGGGTTGACGGTTTCCGATGCCATCCGGTTGCTGATGCTGCGCATTGCCGACGAGCAGCGCCTGCCGTTTGATGTCAAGG
TGCCCAACGCGGAAACGCGGGAGGCCATCGAAGAACTGGAAGCCGGTCGCGGCAAAAAATCCAAGAGTGTCCATGCCCTG
ATGGCAGGGCTGCATGAGGACGATTGA

Structures

Toxin

• AlphaFold DB: U2FZT6