Detailed information of TA system TA151088

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mbcAT/RES(toxin)
• Location: 2262199..2263133
• Replicon: chromosome
• Accession: NZ_CP049255
• Organism: Microbacterium endophyticum strain DSM 27099

Toxin (Protein)

• Gene name: mbcT
• Uniprot ID: -
• Locus tag: G6N83_RS10540
• Protein ID: WP_165141844.1
• Coordinates: 2262546..2263133 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: mbcA
• Uniprot ID: -
• Locus tag: G6N83_RS10535
• Protein ID: WP_206535809.1
• Coordinates: 2262199..2262549 (+)
• Length: 117 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N83_RS10510	2257285..2257665	-	381	WP_165141838.1	hypothetical protein	-
G6N83_RS10515	2257815..2258321	-	507	WP_165141839.1	hypothetical protein	-
G6N83_RS10520	2258436..2259419	-	984	WP_165141840.1	hypothetical protein	-
G6N83_RS10525	2260083..2260469	-	387	WP_165141841.1	hypothetical protein	-
G6N83_RS13795	2260511..2260711	+	201	WP_206535808.1	hypothetical protein	-
G6N83_RS10530	2260965..2262125	-	1161	WP_165141842.1	hypothetical protein	-
G6N83_RS10535	2262199..2262549	+	351	WP_206535809.1	DUF2384 domain-containing protein	Antitoxin
G6N83_RS10540	2262546..2263133	+	588	WP_165141844.1	RES domain-containing protein	Toxin
G6N83_RS10545	2263398..2264156	+	759	WP_165141845.1	hypothetical protein	-
G6N83_RS10550	2264277..2264429	+	153	WP_165141847.1	hypothetical protein	-
G6N83_RS10555	2264543..2265754	-	1212	WP_165141849.1	hypothetical protein	-
G6N83_RS10560	2266583..2268019	-	1437	WP_165141851.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2229533..2268019	38486

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (26-161)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (73-113)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 20993.69 Da
• Isoelectric Point: 4.8677

>T151088 WP_165141844.1 NZ_CP049255:2262546-2263133 [Microbacterium endophyticum]
MNGELDENLVERIDELPRRAISETFHRYATSRRDPLSGAGARAFGGRWNPRDIFGAIYLATPIDACAGEARRAASALATT
PETMLEASYLLHTIAVDDVLVLDLTDPEVLEKLGLTLADVADDDWTACQSVGHAAWFLGFQGVLAPSASGAGLVLAAFEG
RLELHQLAVKDSVPFTPHLYRSLSGSTVHVRGTHL

Nucleotide

• Length: 588 bp

>T151088 NZ_CP065230:1535506-1535775 [Halomonas sp. A40-4]
ATGCCAGAGATTGATGCTCTGCTCGGGCTTTCATTTTGTATGTATTTTTTTGATAACAAGCAGCACAAGCTTCCTCACCT
GCACGTCAAATATGGTGGCTATGAACTGATAATCGCAATTGAGTCAGGTGAGTGCTTGGAGGGATATCTGCCCAATAAGC
ATCGTAAGCGGGCAGAAAACCACATTGCTGAGCATCGGGAGCAGCTAATGCATATGTGGCAGAAAGCAGTCAATGGTGAA
AACCCAGGCAAATTAGGTGACATATGTTAA

Antitoxin

Protein

• Length: 117 a.a.
• Molecular weight: 12629.46 Da
• Isoelectric Point: 5.5802

>AT151088 WP_206535809.1 NZ_CP049255:2262199-2262549 [Microbacterium endophyticum]
MNVNTATALAHKVSNIIDQLGLTQEEVGAIVDASARSVARWSMGDVVPQRLNKARLLELAYVAGAVTEILPASQANLWMF
TPSRLLNHDTPAQRIHDGRYRDVLDLIEAIADGIVV

Nucleotide

• Length: 351 bp

>AT151088 NZ_CP065230:1535769-1536290 [Halomonas sp. A40-4]
ATGTTAAAAATCATTGATGTGGACTTGGTTGGGTCATATACGCTTGAACTGGTTTTTAGCGATGGTTTTCATGGCGTTGC
TGATCTATCAGGCTATTTTAGCAAGGCTCCTTTTTCAGGGATTAAAGACTTCCAAAAGTTCTCACTAACCGCGGCTGGGT
CGCTCAACTGGGGTGGCAATGAGCTTTCTGCGAGCACCCTGCGTGCAGTGACAAAAGGCGTGCAGAAAACAGCAGCCACT
CACTTCAATGTGCAGGAAATGGAAGACGTTATTAAGCAAGCCTCATGGGACTCTATGCAGGAAGGGCGTCCCGACATTTT
ACAGGCTGCTATTCGTTCCTACGTGGAGCAGTTCGGGCATAGCCAGGTCATTGCCAAAGCAGGTATCAAAAGCCGTACCA
GCGCCTATCGTTCTCTAAAGCCACAAACCACCCCCAATTTCGCCACCTTGGTTCAACTGGGGCATGCGGTCATCGAATTA
GCAAAAGAGAATGTCAGTGAGCGTTCTACAGCACAGCGATAA