Detailed information of TA system TA151076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 208494..209088
• Replicon: chromosome
• Accession: NZ_CP049241
• Organism: Rhizobium pseudoryzae strain DSM 19479

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: G6N78_RS01210
• Protein ID: WP_165214823.1
• Coordinates: 208900..209088 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: G6N78_RS01205
• Protein ID: WP_165214820.1
• Coordinates: 208494..208895 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N78_RS01175	203790..204530	+	741	WP_165214802.1	ABC transporter ATP-binding protein	-
G6N78_RS01180	204527..205399	+	873	WP_165214805.1	metal ABC transporter permease	-
G6N78_RS01185	205417..206316	+	900	WP_165214808.1	metal ABC transporter substrate-binding protein	-
G6N78_RS01190	206535..206843	-	309	WP_165214811.1	Dabb family protein	-
G6N78_RS01195	206890..207336	-	447	WP_165214814.1	ribonuclease HI	-
G6N78_RS01200	207333..208304	-	972	WP_165214817.1	homoserine kinase	-
G6N78_RS01205	208494..208895	-	402	WP_165214820.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
G6N78_RS01210	208900..209088	-	189	WP_165214823.1	type II toxin-antitoxin system HicA family toxin	Toxin
G6N78_RS01215	209200..210204	-	1005	WP_165214826.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
G6N78_RS01220	210209..210574	-	366	WP_165214829.1	DUF1304 domain-containing protein	-
G6N78_RS01225	210625..211389	-	765	WP_165214832.1	SURF1 family protein	-
G6N78_RS01230	211358..211741	-	384	WP_165214835.1	DUF983 domain-containing protein	-
G6N78_RS01235	211851..212726	-	876	WP_165214838.1	cytochrome c oxidase subunit 3	-
G6N78_RS01240	212789..213412	-	624	WP_165214841.1	cytochrome c oxidase assembly protein	-
G6N78_RS01245	213434..213571	-	138	WP_165214843.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (7-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6992.08 Da
• Isoelectric Point: 11.0643

>T151076 WP_165214823.1 NZ_CP049241:c209088-208900 [Rhizobium pseudoryzae]
MRSSDVIAALRADGWYEVTTRGSHVQFKHDTKPGRVTVPHPKRDIPIGTLKNIEKQAALKLR

Nucleotide

• Length: 189 bp

>T151076 NZ_CP065210:478426-478767 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14608.51 Da
• Isoelectric Point: 4.3702

>AT151076 WP_165214820.1 NZ_CP049241:c208895-208494 [Rhizobium pseudoryzae]
MRNFIGLIHKDPDSDYGVSFPDFPGVITAGTDLDDARRMAEEALAFHVEGMIEDGEAIPEPSSLEEVMSVQDNRDAVAVL
VPLKNQAKKAVRLNITLPEDVLEKIDAYAQAHGLTRSGFLAQAARRQMSEMPQ

Nucleotide

• Length: 402 bp

>AT151076 NZ_CP065210:478196-478426 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG