Detailed information of TA system TA151071

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2710022..2710704
• Replicon: chromosome
• Accession: NZ_CP049240
• Organism: Acinetobacter baumannii strain Ax270

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MFABIIPG_RS12660
• Protein ID: WP_002077557.1
• Coordinates: 2710522..2710704 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MFABIIPG_RS12655
• Protein ID: WP_000966687.1
• Coordinates: 2710022..2710426 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MFABIIPG_RS12625 (MFABIIPG_02519)	2706745..2707071	-	327	WP_000721695.1	hypothetical protein	-
MFABIIPG_RS12630 (MFABIIPG_02520)	2707143..2707826	-	684	WP_005123868.1	hypothetical protein	-
MFABIIPG_RS12635 (MFABIIPG_02521)	2707858..2708181	-	324	WP_000523925.1	DUF4236 domain-containing protein	-
MFABIIPG_RS12640	2708190..2708366	-	177	WP_001983384.1	hypothetical protein	-
MFABIIPG_RS12645 (MFABIIPG_02522)	2708523..2708933	-	411	WP_000064169.1	hypothetical protein	-
MFABIIPG_RS12650 (MFABIIPG_02523)	2708948..2709781	-	834	WP_000658554.1	hypothetical protein	-
MFABIIPG_RS12655 (MFABIIPG_02524)	2710022..2710426	-	405	WP_000966687.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MFABIIPG_RS12660 (MFABIIPG_02525)	2710522..2710704	-	183	WP_002077557.1	type II toxin-antitoxin system HicA family toxin	Toxin
MFABIIPG_RS12665 (MFABIIPG_02526)	2711030..2711545	-	516	WP_001185611.1	hypothetical protein	-
MFABIIPG_RS12670 (MFABIIPG_02527)	2711615..2712532	-	918	WP_000094281.1	phage tail tube protein	-
MFABIIPG_RS12675 (MFABIIPG_02528)	2712627..2713724	-	1098	WP_001284998.1	hypothetical protein	-
MFABIIPG_RS12680 (MFABIIPG_02529)	2713724..2714074	-	351	WP_000064573.1	hypothetical protein	-
MFABIIPG_RS12685 (MFABIIPG_02530)	2714171..2714389	-	219	WP_001277691.1	hypothetical protein	-
MFABIIPG_RS12690 (MFABIIPG_02531)	2714391..2714789	-	399	WP_001251874.1	phage tail terminator-like protein	-
MFABIIPG_RS12695 (MFABIIPG_02532)	2714791..2715159	-	369	WP_000539744.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2693951..2736473	42522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6709.86 Da
• Isoelectric Point: 10.5523

>T151071 WP_002077557.1 NZ_CP049240:c2710704-2710522 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVTGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T151071 NZ_CP065202:c4759586-4759188 [Pseudomonas fragi]
ATGCTCAAATTCATGCTCGATACCAACATCTGCATTTTCGTGATCAAAAACCGTCCAGAGTATGTTCGCAGCTATTTCAG
AGTGCATGAGGGGCAGCTGTGCATCAGCACCGTGACGCTCATGGAGTTGATATACGGCGCAGAAAAGTCATCCAACCCAG
AGCAGAACCTGCGGGTTATAGAAGGTTTTGCCGCGCGCCTGGAAGTACTGGCATACGACCAGTTTGCTGCCATTCATACC
GGCCAACTTCGTGCCGAACTGGCCCGTACGGGCAAGCCAATCGGCCCCTATGACCAGATGATTGCCGGCCATGCGCGATC
ACAGGGGCTGATTTTAGTCACCAACAACACCCGTGAATTTGAGCGCGTGCCCGGCTTGCGTATCGAAGACTGGGTATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14664.59 Da
• Isoelectric Point: 4.3543

>AT151071 WP_000966687.1 NZ_CP049240:c2710426-2710022 [Acinetobacter baumannii]
MLYPIAIERGSDNEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPEASDLSTYIDDPAYKGMIWAV
TEIDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT151071 NZ_CP065202:c4759816-4759586 [Pseudomonas fragi]
ATGGAACAAGGGGCTATTTTCTTGAGCAACCGCAGTCAGGCGGTGCGTTTGCCCAAAGCGGCGGCGTTGCCTGACGACGT
AAAGCGCGTTGATATCGTCAGCATCGGCAGGGCTCGAATCATTACCCCCGTGGGGGAGTGCTGGGACAGCTGGTTTGAAG
GTGAAGGTGTCACGCCGGACTTTATGACCGATCGCGATCAGCCCCCTGAGCAGCGACGGGATGATTTTTGA