Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/- |
Location | 478658..479311 | Replicon | chromosome |
Accession | NZ_CP049240 | ||
Organism | Acinetobacter baumannii strain Ax270 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | B0V6V2 |
Locus tag | MFABIIPG_RS02285 | Protein ID | WP_000931890.1 |
Coordinates | 478922..479311 (+) | Length | 130 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | V5V966 |
Locus tag | MFABIIPG_RS02280 | Protein ID | WP_001288210.1 |
Coordinates | 478658..478915 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MFABIIPG_RS02260 (MFABIIPG_00450) | 474174..475181 | + | 1008 | WP_000198631.1 | DNA-directed RNA polymerase subunit alpha | - |
MFABIIPG_RS02265 (MFABIIPG_00451) | 475200..475577 | + | 378 | WP_001216380.1 | 50S ribosomal protein L17 | - |
MFABIIPG_RS02270 (MFABIIPG_00452) | 475758..477248 | + | 1491 | WP_000415133.1 | NAD(P)/FAD-dependent oxidoreductase | - |
MFABIIPG_RS02275 (MFABIIPG_00453) | 477298..478470 | - | 1173 | WP_001190546.1 | acyl-CoA dehydrogenase family protein | - |
MFABIIPG_RS02280 (MFABIIPG_00454) | 478658..478915 | + | 258 | WP_001288210.1 | succinate dehydrogenase assembly factor 2 | Antitoxin |
MFABIIPG_RS02285 (MFABIIPG_00455) | 478922..479311 | + | 390 | WP_000931890.1 | membrane protein | Toxin |
MFABIIPG_RS02290 (MFABIIPG_00457) | 480081..481166 | + | 1086 | WP_000049106.1 | hypothetical protein | - |
MFABIIPG_RS02295 (MFABIIPG_00458) | 481244..481810 | + | 567 | WP_000651536.1 | rhombosortase | - |
MFABIIPG_RS02300 (MFABIIPG_00459) | 481998..484193 | + | 2196 | WP_001158905.1 | TRAP transporter large permease subunit | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 130 a.a. Molecular weight: 15649.98 Da Isoelectric Point: 10.4623
>T151070 WP_000931890.1 NZ_CP049240:478922-479311 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY
Download Length: 390 bp
>T151070 NZ_CP065202:3753524-3754099 [Pseudomonas fragi]
ATGGACATCGAAAAAATCAAAGGGCGCCTCGAATTTCTACGCGAGGCGGAAAAGCTCAAGGATGTACTTAGAAGCGCGCA
CACCTCTTCCGGGCGAACCGAAAGCACGGCAGAGCACAGCTGGCGCTTATGCCTGATGGCCGTCGTCTTTGGAGATTATC
TGACCGGTCTCGACAGGTTAAAAATGCTCAAGATGTGTGTCATTCACGACTTGGGAGAGGCCATCAGCGGTGACATTCCC
GCCGTCAATAAAGATTCGTTTCCCAACAAGAGCGAGCAAGAGAGGAACGACCTCATTCTCTTGACCAATACTCTGGATGA
ATCATTAAAAGCCGAGATATTGGCACTTTGGGACGACTACGAAAATGCTTTGTCACCAGAGGCGGTAGCCGTCAAGGCGC
TAGATAAGTTGGAAACAATGCTTCAGCACAACCAAGGCAAGAACCCACCGGACTTCGATTACGAATTCAATCTTGCCTAT
GGCAAAAAATACACAGATGCTGCCCCTCTATTCGAGGCGCTTCGCAATATCATCGACGAAGAAACCAAAGCTAATATGCT
TTTGAATCCGAAATAA
ATGGACATCGAAAAAATCAAAGGGCGCCTCGAATTTCTACGCGAGGCGGAAAAGCTCAAGGATGTACTTAGAAGCGCGCA
CACCTCTTCCGGGCGAACCGAAAGCACGGCAGAGCACAGCTGGCGCTTATGCCTGATGGCCGTCGTCTTTGGAGATTATC
TGACCGGTCTCGACAGGTTAAAAATGCTCAAGATGTGTGTCATTCACGACTTGGGAGAGGCCATCAGCGGTGACATTCCC
GCCGTCAATAAAGATTCGTTTCCCAACAAGAGCGAGCAAGAGAGGAACGACCTCATTCTCTTGACCAATACTCTGGATGA
ATCATTAAAAGCCGAGATATTGGCACTTTGGGACGACTACGAAAATGCTTTGTCACCAGAGGCGGTAGCCGTCAAGGCGC
TAGATAAGTTGGAAACAATGCTTCAGCACAACCAAGGCAAGAACCCACCGGACTTCGATTACGAATTCAATCTTGCCTAT
GGCAAAAAATACACAGATGCTGCCCCTCTATTCGAGGCGCTTCGCAATATCATCGACGAAGAAACCAAAGCTAATATGCT
TTTGAATCCGAAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10318.77 Da Isoelectric Point: 4.6150
>AT151070 WP_001288210.1 NZ_CP049240:478658-478915 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG
Download Length: 258 bp
>AT151070 NZ_CP065202:3752861-3753418 [Pseudomonas fragi]
ATGCCTGATATGTTGCTAAAACCTTCGTTGCCTGGAGTCATGCTCCGGCGATGGCGTCTCTTGCACCAAGTCAAACAATC
CCATGCCGCAGAGTTGTTTAGCGTTACCCAATCAACTATCTCTCGCTGGGAAAGTGGCGTACTGGATTTGGACTCCCTCG
CACACGAAAAGCTTGAGAAGTTGCTGACTGCTCGCCTCACTACAGCCGCTGATCAAGCGCTGGGCCGAATGGTTCGTGAA
AGCTCGCGCCCCGTTCATCTCATTTGTGATTTGACGCACCGTTTGCTTGCTTGTTCATCTTCGCGAGCAGCCCAGTTCGC
GAGTCCTGTCAGCGAGCTGCTGGGTAGTTCTTTATGGCGCTTCGCTACGCCAACTATTATCAGCATGGAAGCTGACCTGG
ATAGATTGGGTTGGCGGGAAGCCTTCGCCCCCCCAGCGCTGGAATTTTTAACGGGCGACAATCATTCGTCCATTGTTCCG
ATCAGCCAAGGCTTATGTCGCTGGACACGAATCCCCCTTTCGGACGGAGCAACAACACGCCTGGTTGAGTCGCTCTAA
ATGCCTGATATGTTGCTAAAACCTTCGTTGCCTGGAGTCATGCTCCGGCGATGGCGTCTCTTGCACCAAGTCAAACAATC
CCATGCCGCAGAGTTGTTTAGCGTTACCCAATCAACTATCTCTCGCTGGGAAAGTGGCGTACTGGATTTGGACTCCCTCG
CACACGAAAAGCTTGAGAAGTTGCTGACTGCTCGCCTCACTACAGCCGCTGATCAAGCGCTGGGCCGAATGGTTCGTGAA
AGCTCGCGCCCCGTTCATCTCATTTGTGATTTGACGCACCGTTTGCTTGCTTGTTCATCTTCGCGAGCAGCCCAGTTCGC
GAGTCCTGTCAGCGAGCTGCTGGGTAGTTCTTTATGGCGCTTCGCTACGCCAACTATTATCAGCATGGAAGCTGACCTGG
ATAGATTGGGTTGGCGGGAAGCCTTCGCCCCCCCAGCGCTGGAATTTTTAACGGGCGACAATCATTCGTCCATTGTTCCG
ATCAGCCAAGGCTTATGTCGCTGGACACGAATCCCCCTTTCGGACGGAGCAACAACACGCCTGGTTGAGTCGCTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J1A4U0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BQM7 |