Detailed information of TA system TA151068

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 50554..51082
• Replicon: chromosome
• Accession: NZ_CP049234
• Organism: Campylobacter concisus strain P15UCO-S2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U2FZT6
• Locus tag: G5B99_RS00245
• Protein ID: WP_021084979.1
• Coordinates: 50554..50841 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G5B99_RS00250
• Protein ID: WP_084042015.1
• Coordinates: 50831..51082 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5B99_RS09660	45936..46280	+	345	WP_009295465.1	hypothetical protein	-
G5B99_RS00225	46478..47315	+	838	Protein_40	ATP-binding protein	-
G5B99_RS00230	47378..47551	+	174	WP_009295461.1	transposon-encoded TnpW family protein	-
G5B99_RS00235	48218..49810	-	1593	WP_103606168.1	relaxase/mobilization nuclease domain-containing protein	-
G5B99_RS00240	49858..50187	-	330	WP_103606169.1	hypothetical protein	-
G5B99_RS00245	50554..50841	-	288	WP_021084979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G5B99_RS00250	50831..51082	-	252	WP_084042015.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
G5B99_RS00255	51164..52945	-	1782	WP_107892578.1	site-specific integrase	-
G5B99_RS00260	54252..54554	+	303	WP_035142770.1	hypothetical protein	-
G5B99_RS00265	54532..55077	+	546	WP_107848039.1	hypothetical protein	-
G5B99_RS00270	55230..55592	+	363	WP_084109992.1	plasmid mobilization relaxosome protein MobC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	30518..74445	43927

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11387.25 Da
• Isoelectric Point: 9.5216

>T151068 WP_021084979.1 NZ_CP049234:c50841-50554 [Campylobacter concisus]
MSYELEFLPSALKEWQKLDNSIKVQFKKKLSERLENPKVTKDKLRGYEDVYKIKLRDVGYRLAYQVKDDEIVVLVLVVGK
RENNEVYEMLKDKFN

Nucleotide

• Length: 288 bp

>T151068 NZ_CP065202:421827-422024 [Pseudomonas fragi]
ATGCGAAGTCGTGAACTTATCGAGTTGCTGATGGCGGATGGGTGGTTTGAGATCGCGGTTAAAGGAAGTCACCATCAGTT
CAAGCACCCAGCCAAAGCGGGTCGGGTAACGGTTCCGCATCCCAGGACAGAAATTGCCAAAGGGACGCTGCACAGCATTC
TCAAATCCGCAGGTCTCAAAGGAGAGTTACGGTCATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8954.26 Da
• Isoelectric Point: 4.9901

>AT151068 WP_084042015.1 NZ_CP049234:c51082-50831 [Campylobacter concisus]
MQTIQANFTASISELKKSPAQILKQAGDNVVAILNHNVPSAYLVPSSVYEKMAEIIEEYHLSKAVDAALASGEKPVKVSL
DEL

Nucleotide

• Length: 252 bp

>AT151068 NZ_CP065202:422021-422431 [Pseudomonas fragi]
ATGAAATTTCCAGTGGTAATACATAAAGACGCAGATTCTGAATTCAGCGTGACGGTGCCTGATGTGCCGGGCTGTTTTTC
TGCAGGGGCTACCTTTTCGCAAGCGCTGGATAACGTGCAGGAAGCATTGGCTTTGCATCTGGAAGGCATTGTTGCGGACG
GCGGTGAGCTACCCCAGGGCAAGGACGTGGACGCCCATCTGGAGAATCCGGATTATGTCGGCGGGATATGGGCAATCGTT
GACTTTGATTTGACGCCTTATCTCGGCAAGTCGGTTCGGTTCAACGCGTCGTTGCCAGAGAATCTGTTGCAGCGCATCGA
TGAACGAGTCAGCAGGGACCACCGCTATGCGTCCCGTTCAGGGTTTCTGGCAACAGCGGCATTGCGCGAGCTGAGCGTTC
AGAACTTTTGA

Structures

Toxin

• AlphaFold DB: U2FZT6