Detailed information of TA system TA151066

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 340945..341473
• Replicon: chromosome
• Accession: NZ_CP049232
• Organism: Campylobacter concisus strain H9O-S2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M5IRL2
• Locus tag: G5B96_RS01715
• Protein ID: WP_009295458.1
• Coordinates: 341186..341473 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M5IPY6
• Locus tag: G5B96_RS01710
• Protein ID: WP_009295321.1
• Coordinates: 340945..341196 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5B96_RS01700	337367..338131	+	765	WP_158335202.1	DUF996 domain-containing protein	-
G5B96_RS01705	339091..340863	+	1773	WP_196088925.1	site-specific integrase	-
G5B96_RS01710	340945..341196	+	252	WP_009295321.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
G5B96_RS01715	341186..341473	+	288	WP_009295458.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G5B96_RS01720	341840..342181	+	342	WP_196088926.1	hypothetical protein	-
G5B96_RS01725	342217..343809	+	1593	WP_149700063.1	relaxase/mobilization nuclease domain-containing protein	-
G5B96_RS01730	344477..344650	-	174	WP_009295461.1	transposon-encoded TnpW family protein	-
G5B96_RS01735	344712..345549	-	838	Protein_332	ATP-binding protein	-
G5B96_RS09965	345748..346092	-	345	WP_009295465.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11299.19 Da
• Isoelectric Point: 9.7349

>T151066 WP_009295458.1 NZ_CP049232:341186-341473 [Campylobacter concisus]
MSYELEFLPGALKEWQKLDNSIKVQFKKKLSERLENPKVAKDKLRGYEDVYKIKLRDVGYRLAYQVKDSEIVVLVLVVGK
RENNEVYEMLKDKFN

Nucleotide

• Length: 288 bp

>T151066 NZ_CP065199:c2465768-2465502 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8938.26 Da
• Isoelectric Point: 4.9901

>AT151066 WP_009295321.1 NZ_CP049232:340945-341196 [Campylobacter concisus]
MQTIQANFTASISELKKSPAQILKQAGDNVVAILNHNVPSAYLVPSAVYEKMAEIIEEYHLSKAVDAALASGEKPVKVSL
DEL

Nucleotide

• Length: 252 bp

>AT151066 NZ_CP065199:c2466025-2465768 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Toxin

• AlphaFold DB: M5IRL2

Antitoxin

• AlphaFold DB: M5IPY6