Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/YafQ-DinJ |
Location | 666079..666647 | Replicon | chromosome |
Accession | NZ_CP049231 | ||
Organism | Lactobacillus iners strain C0254C1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | G6Z81_RS03445 | Protein ID | WP_164799433.1 |
Coordinates | 666369..666647 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | G6Z81_RS03440 | Protein ID | WP_006736912.1 |
Coordinates | 666079..666363 (+) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
G6Z81_RS03415 | 661903..663312 | - | 1410 | WP_164799431.1 | RsmF rRNA methyltransferase first C-terminal domain-containing protein | - |
G6Z81_RS03420 | 663312..664292 | - | 981 | WP_006738135.1 | hypothetical protein | - |
G6Z81_RS03425 | 664279..665025 | - | 747 | WP_164799432.1 | SAM-dependent methyltransferase | - |
G6Z81_RS03430 | 665113..665715 | + | 603 | WP_006729930.1 | signal peptidase I | - |
G6Z81_RS03435 | 665731..665916 | + | 186 | WP_006732263.1 | hypothetical protein | - |
G6Z81_RS03440 | 666079..666363 | + | 285 | WP_006736912.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
G6Z81_RS03445 | 666369..666647 | + | 279 | WP_164799433.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
G6Z81_RS03450 | 667083..667796 | - | 714 | WP_006738361.1 | M48 family metallopeptidase | - |
G6Z81_RS03455 | 668066..668350 | + | 285 | WP_102215227.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
G6Z81_RS03460 | 668651..669541 | - | 891 | WP_006736250.1 | GIY-YIG nuclease family protein | - |
G6Z81_RS06595 | 669912..670124 | + | 213 | WP_035511922.1 | hypothetical protein | - |
G6Z81_RS03470 | 670387..671076 | - | 690 | WP_006736915.1 | ABC transporter ATP-binding protein | - |
G6Z81_RS03475 | 671069..671443 | - | 375 | WP_006731653.1 | GntR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10835.61 Da Isoelectric Point: 9.0049
>T151065 WP_164799433.1 NZ_CP049231:666369-666647 [Lactobacillus iners]
MLQLKTTSKFRKDYRRIKKRGLDIYLLKEVLDKLCARETLDLKYKDHALSGSYQGFRECHIQPDWLLIYAISEDEIILVA
SRTGSHADLFNM
MLQLKTTSKFRKDYRRIKKRGLDIYLLKEVLDKLCARETLDLKYKDHALSGSYQGFRECHIQPDWLLIYAISEDEIILVA
SRTGSHADLFNM
Download Length: 279 bp
>T151065 NZ_CP065199:c2434022-2433915 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10516.02 Da Isoelectric Point: 5.1231
>AT151065 WP_006736912.1 NZ_CP049231:666079-666363 [Lactobacillus iners]
MAKTANINVRIEPEVKQQAEDLFGSFGISVTDAINIFLRTSIMEGGFPFKIRKPRFNAETLAAMQEARDIMSGKIQAKSY
KTTDEFIQALNAED
MAKTANINVRIEPEVKQQAEDLFGSFGISVTDAINIFLRTSIMEGGFPFKIRKPRFNAETLAAMQEARDIMSGKIQAKSY
KTTDEFIQALNAED
Download Length: 285 bp
>AT151065 NZ_CP065199:2433838-2433898 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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