Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapC-vagC/VapC-VagC |
Location | 1250627..1251264 | Replicon | chromosome |
Accession | NZ_CP049214 | ||
Organism | Agrobacterium rhizogenes strain CA75/95 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A5M8ULE8 |
Locus tag | G6M87_RS25440 | Protein ID | WP_034515896.1 |
Coordinates | 1250863..1251264 (+) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | B9JLI6 |
Locus tag | G6M87_RS25435 | Protein ID | WP_007702100.1 |
Coordinates | 1250627..1250863 (+) | Length | 79 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
G6M87_RS25420 (G6M87_25495) | 1245859..1246509 | - | 651 | WP_015917982.1 | TetR/AcrR family transcriptional regulator | - |
G6M87_RS25425 (G6M87_25500) | 1246636..1247925 | + | 1290 | WP_015917981.1 | MFS transporter | - |
G6M87_RS25430 (G6M87_25505) | 1247999..1250455 | + | 2457 | WP_015917980.1 | glycoside hydrolase family 3 C-terminal domain-containing protein | - |
G6M87_RS25435 (G6M87_25510) | 1250627..1250863 | + | 237 | WP_007702100.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
G6M87_RS25440 (G6M87_25515) | 1250863..1251264 | + | 402 | WP_034515896.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
G6M87_RS25445 (G6M87_25520) | 1251391..1252488 | - | 1098 | WP_015917978.1 | branched-chain amino acid aminotransferase | - |
G6M87_RS25450 (G6M87_25525) | 1252638..1253552 | - | 915 | WP_015917977.1 | DUF1194 domain-containing protein | - |
G6M87_RS25455 (G6M87_25530) | 1253572..1254189 | - | 618 | WP_015917976.1 | LysE family translocator | - |
G6M87_RS25460 (G6M87_25535) | 1254411..1255070 | - | 660 | WP_007702087.1 | response regulator transcription factor | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14951.22 Da Isoelectric Point: 5.6421
>T151064 WP_034515896.1 NZ_CP049214:1250863-1251264 [Agrobacterium rhizogenes]
MPRYMLDTNMCIYLMKNQPEQVARRFAACYVGDVVMSAITFAELDYGVAASDAPERERGNLDALVTLIAVEPFDIAAAHA
YGPVRMATRERKKDHLDKLIASHAIALNTVLVTNNTRDFMAYPNLKIENWLDT
MPRYMLDTNMCIYLMKNQPEQVARRFAACYVGDVVMSAITFAELDYGVAASDAPERERGNLDALVTLIAVEPFDIAAAHA
YGPVRMATRERKKDHLDKLIASHAIALNTVLVTNNTRDFMAYPNLKIENWLDT
Download Length: 402 bp
>T151064 NZ_CP065199:c2408871-2408605 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 9020.18 Da Isoelectric Point: 4.6561
>AT151064 WP_007702100.1 NZ_CP049214:1250627-1250863 [Agrobacterium rhizogenes]
MQMTKAFKNGNSQAVRIPAEIAYERTDMELEIERVGDEIRIRPVRQSLAGVMDVFARFSPNFMSEGRGDQEQDEREKI
MQMTKAFKNGNSQAVRIPAEIAYERTDMELEIERVGDEIRIRPVRQSLAGVMDVFARFSPNFMSEGRGDQEQDEREKI
Download Length: 237 bp
>AT151064 NZ_CP065199:c2409122-2408871 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5M8ULE8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5M8UQQ5 |