Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 1250627..1251264 Replicon chromosome
Accession NZ_CP049214
Organism Agrobacterium rhizogenes strain CA75/95

Toxin (Protein)


Gene name vapC Uniprot ID A0A5M8ULE8
Locus tag G6M87_RS25440 Protein ID WP_034515896.1
Coordinates 1250863..1251264 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B9JLI6
Locus tag G6M87_RS25435 Protein ID WP_007702100.1
Coordinates 1250627..1250863 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M87_RS25420 (G6M87_25495) 1245859..1246509 - 651 WP_015917982.1 TetR/AcrR family transcriptional regulator -
G6M87_RS25425 (G6M87_25500) 1246636..1247925 + 1290 WP_015917981.1 MFS transporter -
G6M87_RS25430 (G6M87_25505) 1247999..1250455 + 2457 WP_015917980.1 glycoside hydrolase family 3 C-terminal domain-containing protein -
G6M87_RS25435 (G6M87_25510) 1250627..1250863 + 237 WP_007702100.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6M87_RS25440 (G6M87_25515) 1250863..1251264 + 402 WP_034515896.1 type II toxin-antitoxin system VapC family toxin Toxin
G6M87_RS25445 (G6M87_25520) 1251391..1252488 - 1098 WP_015917978.1 branched-chain amino acid aminotransferase -
G6M87_RS25450 (G6M87_25525) 1252638..1253552 - 915 WP_015917977.1 DUF1194 domain-containing protein -
G6M87_RS25455 (G6M87_25530) 1253572..1254189 - 618 WP_015917976.1 LysE family translocator -
G6M87_RS25460 (G6M87_25535) 1254411..1255070 - 660 WP_007702087.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-117)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14951.22 Da        Isoelectric Point: 5.6421

>T151064 WP_034515896.1 NZ_CP049214:1250863-1251264 [Agrobacterium rhizogenes]
MPRYMLDTNMCIYLMKNQPEQVARRFAACYVGDVVMSAITFAELDYGVAASDAPERERGNLDALVTLIAVEPFDIAAAHA
YGPVRMATRERKKDHLDKLIASHAIALNTVLVTNNTRDFMAYPNLKIENWLDT

Download         Length: 402 bp

>T151064 NZ_CP065199:c2408871-2408605 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9020.18 Da        Isoelectric Point: 4.6561

>AT151064 WP_007702100.1 NZ_CP049214:1250627-1250863 [Agrobacterium rhizogenes]
MQMTKAFKNGNSQAVRIPAEIAYERTDMELEIERVGDEIRIRPVRQSLAGVMDVFARFSPNFMSEGRGDQEQDEREKI

Download         Length: 237 bp

>AT151064 NZ_CP065199:c2409122-2408871 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M8ULE8

Antitoxin

Source ID Structure
AlphaFold DB A0A5M8UQQ5

References