Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 781111..781658 Replicon chromosome
Accession NZ_CP049214
Organism Agrobacterium rhizogenes strain CA75/95

Toxin (Protein)


Gene name parE Uniprot ID A0A5M8UJE8
Locus tag G6M87_RS23305 Protein ID WP_037222627.1
Coordinates 781365..781658 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID B9JNC7
Locus tag G6M87_RS23300 Protein ID WP_012649398.1
Coordinates 781111..781365 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M87_RS23275 (G6M87_23320) 777633..777980 - 348 WP_012478058.1 IS66 family insertion sequence element accessory protein TnpB -
G6M87_RS23280 (G6M87_23325) 777977..778861 - 885 WP_208309705.1 transposase -
G6M87_RS23285 (G6M87_23330) 779272..779571 + 300 WP_037222128.1 hypothetical protein -
G6M87_RS23290 (G6M87_23335) 779583..780011 + 429 WP_034522328.1 universal stress protein -
G6M87_RS23295 (G6M87_23340) 780566..780742 - 177 WP_012649397.1 hypothetical protein -
G6M87_RS23300 (G6M87_23345) 781111..781365 + 255 WP_012649398.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
G6M87_RS23305 (G6M87_23350) 781365..781658 + 294 WP_037222627.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6M87_RS23310 (G6M87_23355) 782026..783093 + 1068 WP_234905109.1 nucleotidyltransferase family protein -
G6M87_RS23315 (G6M87_23360) 783090..784169 - 1080 WP_037222698.1 transporter -
G6M87_RS23320 (G6M87_23365) 784190..784414 - 225 WP_007689697.1 hypothetical protein -
G6M87_RS23325 (G6M87_23370) 784997..785218 + 222 WP_007689698.1 hypothetical protein -
G6M87_RS23330 (G6M87_23375) 785408..785872 + 465 WP_012649402.1 VOC family protein -
G6M87_RS23335 (G6M87_23380) 785901..786239 - 339 WP_007689700.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-92)

Antitoxin

Antitoxin ParD

(3-70)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11208.78 Da        Isoelectric Point: 5.9024

>T151063 WP_037222627.1 NZ_CP049214:781365-781658 [Agrobacterium rhizogenes]
MRFSLFVEAEEDIIAIAEQGVRLFGSAHAKRYHDELFSLLDLIAANPRMAREREEISPPVRIHPFKAHLVVYRIEEDGAI
FVIRIRHGHEDWASDSV

Download         Length: 294 bp

>T151063 NZ_CP065199:c2149611-2149507 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9362.53 Da        Isoelectric Point: 8.5688

>AT151063 WP_012649398.1 NZ_CP049214:781111-781365 [Agrobacterium rhizogenes]
MATMNVSLPDPMKDWVEAQAKTGRYSNASDYVRDLIRRDQVRSDKIAAMQRFVDDGLKSGVGGRSKDELFATAIAHGEMT
RGDR

Download         Length: 255 bp

>AT151063 NZ_CP065199:2149414-2149452 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M8UJE8

Antitoxin

Source ID Structure
AlphaFold DB A0A5M8UM94

References