Detailed information of TA system TA151062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 3551906..3552425
• Replicon: chromosome
• Accession: NZ_CP049213
• Organism: Agrobacterium rhizogenes strain CA75/95

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: G6M87_RS17580
• Protein ID: WP_047468554.1
• Coordinates: 3552144..3552425 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B9JBR8
• Locus tag: G6M87_RS17575
• Protein ID: WP_012652580.1
• Coordinates: 3551906..3552154 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6M87_RS17550 (G6M87_17575)	3547595..3548542	+	948	WP_065707345.1	ABC transporter permease	-
G6M87_RS17555 (G6M87_17580)	3548627..3549334	+	708	WP_065707362.1	YdcF family protein	-
G6M87_RS17560 (G6M87_17585)	3549433..3550233	+	801	WP_012652577.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
G6M87_RS17565 (G6M87_17590)	3550230..3550763	-	534	WP_012652578.1	gamma-glutamylcyclotransferase	-
G6M87_RS17570 (G6M87_17595)	3550815..3551828	+	1014	WP_012652579.1	DUF2125 domain-containing protein	-
G6M87_RS17575 (G6M87_17600)	3551906..3552154	+	249	WP_012652580.1	antitoxin	Antitoxin
G6M87_RS17580 (G6M87_17605)	3552144..3552425	+	282	WP_047468554.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6M87_RS17585 (G6M87_17610)	3552472..3553401	-	930	WP_012652582.1	prephenate/arogenate dehydrogenase family protein	-
G6M87_RS17590 (G6M87_17615)	3553398..3554507	-	1110	WP_047468556.1	histidinol-phosphate transaminase	-
G6M87_RS17595 (G6M87_17620)	3554611..3555390	-	780	WP_007693610.1	class I SAM-dependent methyltransferase	-
G6M87_RS17600 (G6M87_17625)	3555446..3556216	+	771	WP_007693609.1	hydroxyacylglutathione hydrolase	-
G6M87_RS17605 (G6M87_17630)	3556216..3556641	+	426	WP_034521573.1	cupin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11054.88 Da
• Isoelectric Point: 10.6226

>T151062 WP_047468554.1 NZ_CP049213:3552144-3552425 [Agrobacterium rhizogenes]
MTYELGFLHAALKEWRKLDANTREQFKKKLAERCENPRVPSAKLFGSKDRYKIKLRGVGYRLVYEVRDEQLVIIVVAVGK
RERNEIYRAADRR

Nucleotide

• Length: 282 bp

>T151062 NZ_CP065199:c2092368-2092159 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8775.18 Da
• Isoelectric Point: 4.3466

>AT151062 WP_012652580.1 NZ_CP049213:3551906-3552154 [Agrobacterium rhizogenes]
MTNVILAEVTASVSELKKNPMGTVAAGEGATVAILNRNAPAFYCVPARLYEAMLDRLEDMELNAIADARAGEPIIKVKLD
DL

Nucleotide

• Length: 249 bp

>AT151062 NZ_CP065199:c2092673-2092380 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A5M8UL61