Detailed information of TA system TA151061

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1680977..1681511
• Replicon: chromosome
• Accession: NZ_CP049213
• Organism: Agrobacterium rhizogenes strain CA75/95

Toxin (Protein)

• Gene name: parE
• Uniprot ID: B9JDM3
• Locus tag: G6M87_RS08205
• Protein ID: WP_007692021.1
• Coordinates: 1681212..1681511 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B9JDM2
• Locus tag: G6M87_RS08200
• Protein ID: WP_007692023.1
• Coordinates: 1680977..1681222 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6M87_RS08180 (G6M87_08195)	1676150..1676770	-	621	WP_012651243.1	glycerol-3-phosphate 1-O-acyltransferase PlsY	-
G6M87_RS08185 (G6M87_08200)	1676800..1678089	-	1290	WP_007692030.1	dihydroorotase	-
G6M87_RS08190 (G6M87_08205)	1678086..1679042	-	957	WP_007692028.1	aspartate carbamoyltransferase catalytic subunit	-
G6M87_RS08195 (G6M87_08210)	1679225..1680883	+	1659	WP_007692026.1	acyl-CoA dehydrogenase family protein	-
G6M87_RS08200 (G6M87_08215)	1680977..1681222	+	246	WP_007692023.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
G6M87_RS08205 (G6M87_08220)	1681212..1681511	+	300	WP_007692021.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6M87_RS08210 (G6M87_08225)	1681576..1682193	+	618	WP_037220613.1	GNAT family N-acetyltransferase	-
G6M87_RS08215 (G6M87_08230)	1682297..1682956	+	660	WP_012651244.1	TetR/AcrR family transcriptional regulator	-
G6M87_RS08220 (G6M87_08235)	1683086..1683259	+	174	WP_165586803.1	hypothetical protein	-
G6M87_RS08225 (G6M87_08240)	1683256..1683588	+	333	WP_007692017.1	DUF6105 family protein	-
G6M87_RS08230 (G6M87_08245)	1683525..1684019	-	495	WP_007692016.1	Holliday junction resolvase RuvX	-
G6M87_RS08235 (G6M87_08250)	1684136..1684846	+	711	WP_007692015.1	metal-dependent hydrolase	-
G6M87_RS08240 (G6M87_08255)	1684914..1685201	+	288	WP_007692014.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11335.87 Da
• Isoelectric Point: 6.4816

>T151061 WP_007692021.1 NZ_CP049213:1681212-1681511 [Agrobacterium rhizogenes]
MASKSGRYVLSPLAEADLEEIWRYTAENWSVKQAETYHAGILDAFEGLASGLKVGRYADIREGYFKYVVGSHVIYYRQQD
TEIAVIRILHQRMDVGLHL

Nucleotide

• Length: 300 bp

>T151061 NZ_CP065199:c2072781-2072419 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8768.84 Da
• Isoelectric Point: 7.2019

>AT151061 WP_007692023.1 NZ_CP049213:1680977-1681222 [Agrobacterium rhizogenes]
MARNTSVSLGDHFNTFIDAQVQTGRYGSASDVVRAGLRLLEEHEAKVKALQGALIAGEESGKPTPFDNAAFLKRMRATYG
E

Nucleotide

• Length: 246 bp

>AT151061 NZ_CP065199:c2072948-2072778 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: B9JDM3

Antitoxin

• AlphaFold DB: B9JDM2