Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 659091..659725 Replicon chromosome
Accession NZ_CP049213
Organism Agrobacterium rhizogenes strain CA75/95

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6M87_RS03145 Protein ID WP_007702741.1
Coordinates 659091..659486 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B9J7R9
Locus tag G6M87_RS03150 Protein ID WP_007702738.1
Coordinates 659483..659725 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M87_RS03115 (G6M87_03125) 654105..654560 + 456 WP_007702750.1 ester cyclase -
G6M87_RS03120 (G6M87_03130) 654623..655387 - 765 WP_007702749.1 SDR family oxidoreductase -
G6M87_RS03125 (G6M87_03135) 655507..656412 + 906 WP_007702748.1 LysR family transcriptional regulator -
G6M87_RS03130 (G6M87_03140) 656413..657288 - 876 WP_007702747.1 LysR family transcriptional regulator -
G6M87_RS03135 (G6M87_03145) 657386..658669 + 1284 WP_007702745.1 MFS transporter -
G6M87_RS03140 (G6M87_03150) 658693..659094 + 402 WP_007702743.1 VOC family protein -
G6M87_RS03145 (G6M87_03155) 659091..659486 - 396 WP_007702741.1 type II toxin-antitoxin system VapC family toxin Toxin
G6M87_RS03150 (G6M87_03160) 659483..659725 - 243 WP_007702738.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G6M87_RS03155 (G6M87_03165) 659794..660471 - 678 WP_007702735.1 spermidine synthase -
G6M87_RS03160 (G6M87_03170) 660542..662203 - 1662 WP_007702732.1 urocanate hydratase -
G6M87_RS03165 (G6M87_03175) 662227..662556 - 330 WP_007702728.1 TfoX/Sxy family protein -
G6M87_RS03170 (G6M87_03180) 662572..663672 - 1101 WP_007702725.1 DUF917 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14661.85 Da        Isoelectric Point: 7.4004

>T151059 WP_007702741.1 NZ_CP049213:c659486-659091 [Agrobacterium rhizogenes]
VKYLLDSNAVIALMKGHSGFVAEIRKHKPQDFAIPAIVAHELFYGAYKGQRVADNLARVDALQFETLDFDREDARKAGEI
RAALAILGTPIGAYNVLIAGQAVARDLILVTHNVREFQRVKNLRFEDWETV

Download         Length: 396 bp

>T151059 NZ_CP065199:1860144-1860239 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9333.46 Da        Isoelectric Point: 4.1849

>AT151059 WP_007702738.1 NZ_CP049213:c659725-659483 [Agrobacterium rhizogenes]
MDTAKIFWSGRSQAVRLPKEFRFDTDAVRIRRQGQAIILEPIVEDWDWLETVTGPVDQDFAEAATEQPVEQERPELDIFK

Download         Length: 243 bp

>AT151059 NZ_CP065199:c1860324-1860267 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5M8UM92

References