Detailed information of TA system TA151058

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 453839..454404
• Replicon: chromosome
• Accession: NZ_CP049213
• Organism: Agrobacterium rhizogenes strain CA75/95

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G6M87_RS02075
• Protein ID: WP_198929354.1
• Coordinates: 454159..454404 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B9J6S6
• Locus tag: G6M87_RS02070
• Protein ID: WP_007702948.1
• Coordinates: 453839..454123 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6M87_RS02055 (G6M87_02060)	449647..451284	+	1638	WP_007702958.1	ABC transporter ATP-binding protein	-
G6M87_RS02060 (G6M87_02065)	451296..452255	+	960	WP_007702954.1	glyoxylate/hydroxypyruvate reductase A	-
G6M87_RS02065 (G6M87_02070)	452447..453751	+	1305	WP_007702951.1	nicotinate phosphoribosyltransferase	-
G6M87_RS02070 (G6M87_02075)	453839..454123	+	285	WP_007702948.1	hypothetical protein	Antitoxin
G6M87_RS02075 (G6M87_02080)	454159..454404	+	246	WP_198929354.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6M87_RS02080 (G6M87_02085)	454415..455371	-	957	WP_007702942.1	hypothetical protein	-
G6M87_RS02085 (G6M87_02090)	455550..457724	+	2175	WP_007702939.1	mechanosensitive ion channel	-
G6M87_RS02090 (G6M87_02095)	457809..458867	-	1059	WP_007702937.1	LacI family DNA-binding transcriptional regulator	-
G6M87_RS02095 (G6M87_02100)	459019..459315	+	297	WP_007702934.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-78)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9244.71 Da
• Isoelectric Point: 10.0946

>T151058 WP_198929354.1 NZ_CP049213:454159-454404 [Agrobacterium rhizogenes]
MRQFLQPKNAASAKKASTKIIQTIQMLSNQPDMGRPVEDLHQGLRELIVKFGRDGYVVLYRYIGDEVLIAAIRHGREDGY
K

Nucleotide

• Length: 246 bp

>T151058 NZ_CP065199:c873882-873694 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10784.99 Da
• Isoelectric Point: 4.4877

>AT151058 WP_007702948.1 NZ_CP049213:453839-454123 [Agrobacterium rhizogenes]
MSSALKASVKIDPEVNERLEKLAASRHRQPDLLLKEAVEQYVDREEKRDSLLRDGRLSLDEYEATGLHVTGDEVIAWLET
WGDEDEKAPPECHR

Nucleotide

• Length: 285 bp

>AT151058 NZ_CP065199:c874171-873911 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A5M8UMH1