Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2701865..2702388 Replicon chromosome
Accession NZ_CP049206
Organism Agrobacterium rubi strain W2/73

Toxin (Protein)


Gene name parE Uniprot ID A0A1B9U0E5
Locus tag G6M88_RS12980 Protein ID WP_065698362.1
Coordinates 2701865..2702152 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B9U0D8
Locus tag G6M88_RS12985 Protein ID WP_065698361.1
Coordinates 2702149..2702388 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M88_RS12960 (G6M88_12980) 2697572..2698417 - 846 WP_065698366.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
G6M88_RS12965 (G6M88_12985) 2698435..2700633 + 2199 WP_065698365.1 molybdopterin oxidoreductase family protein -
G6M88_RS12970 (G6M88_12990) 2700646..2701242 + 597 WP_065698364.1 NUDIX domain-containing protein -
G6M88_RS12975 (G6M88_12995) 2701257..2701868 + 612 WP_065698363.1 NUDIX domain-containing protein -
G6M88_RS12980 (G6M88_13000) 2701865..2702152 - 288 WP_065698362.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6M88_RS12985 (G6M88_13005) 2702149..2702388 - 240 WP_065698361.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
G6M88_RS12990 (G6M88_13010) 2702455..2703114 - 660 WP_065698360.1 phosphoribosylglycinamide formyltransferase -
G6M88_RS12995 (G6M88_13015) 2703111..2704184 - 1074 WP_065698459.1 phosphoribosylformylglycinamidine cyclo-ligase -
G6M88_RS13000 (G6M88_13020) 2704422..2705576 + 1155 WP_045231867.1 AI-2E family transporter -
G6M88_RS13005 (G6M88_13025) 2705580..2706293 + 714 WP_065698359.1 DnaA regulatory inactivator HdaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(1-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10702.29 Da        Isoelectric Point: 9.5632

>T151055 WP_065698362.1 NZ_CP049206:c2702152-2701865 [Agrobacterium rubi]
MKALLLTPKARSDIEGIWDYTVDNWGINQAEVYITAIQKALEGLADSSTISQSAESIRKNYRKTIVGSHTVFFKETNAAI
EVVRILHHRMSLARL

Download         Length: 288 bp

>T151055 NZ_CP065194:c1849059-1848955 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8850.88 Da        Isoelectric Point: 4.8550

>AT151055 WP_065698361.1 NZ_CP049206:c2702388-2702149 [Agrobacterium rubi]
MAKSTSVNLNDHFDAFIEQQIEDGRYASASEVLRAGLRLLEEREAELSHLRAALIEGEKSGDAVPFDFREFVRGKKNLG

Download         Length: 240 bp

>AT151055 NZ_CP065194:1848861-1848899 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9U0E5

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9U0D8

References