Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2664282..2664913 Replicon chromosome
Accession NZ_CP049206
Organism Agrobacterium rubi strain W2/73

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B9U0G2
Locus tag G6M88_RS12815 Protein ID WP_065698385.1
Coordinates 2664515..2664913 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B9U0H7
Locus tag G6M88_RS12810 Protein ID WP_065698386.1
Coordinates 2664282..2664515 (+) Length 78 a.a.

Genomic Context

G6M88_RS12785G6M88_RS12790G6M88_RS12795G6M88_RS12800G6M88_RS12805G6M88_RS12810G6M88_RS12815G6M88_RS12820G6M88_RS12825G6M88_RS12830
Location: 2659364..2659600 (237 bp)
Type: Others
Protein ID: WP_006727438.1
Location: 2659844..2661112 (1269 bp)
Type: Others
Protein ID: WP_045231833.1
Location: 2661361..2662584 (1224 bp)
Type: Others
Protein ID: WP_065698388.1
Location: 2662641..2663525 (885 bp)
Type: Others
Protein ID: WP_065698387.1
Location: 2663531..2664202 (672 bp)
Type: Others
Protein ID: WP_045231836.1
Location: 2664282..2664515 (234 bp)
Type: Antitoxin
Protein ID: WP_065698386.1
Location: 2664515..2664913 (399 bp)
Type: Toxin
Protein ID: WP_065698385.1
Location: 2664924..2665766 (843 bp)
Type: Others
Protein ID: WP_065698384.1
Location: 2665766..2666785 (1020 bp)
Type: Others
Protein ID: WP_065698464.1
Location: 2666803..2667747 (945 bp)
Type: Others
Protein ID: WP_065698383.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G6M88_RS12785 (G6M88_12805)2659364..2659600+237WP_006727438.1acyl carrier protein-
G6M88_RS12790 (G6M88_12810)2659844..2661112+1269WP_045231833.1beta-ketoacyl-ACP synthase II-
G6M88_RS12795 (G6M88_12815)2661361..2662584+1224WP_065698388.1endolytic transglycosylase MltG-
G6M88_RS12800 (G6M88_12820)2662641..2663525+885WP_065698387.1YicC/YloC family endoribonuclease-
G6M88_RS12805 (G6M88_12825)2663531..2664202+672WP_045231836.1guanylate kinase-
G6M88_RS12810 (G6M88_12830)2664282..2664515+234WP_065698386.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
G6M88_RS12815 (G6M88_12835)2664515..2664913+399WP_065698385.1tRNA(fMet)-specific endonuclease VapCToxin
G6M88_RS12820 (G6M88_12840)2664924..2665766-843WP_065698384.116S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA-
G6M88_RS12825 (G6M88_12845)2665766..2666785-1020WP_065698464.14-hydroxythreonine-4-phosphate dehydrogenase PdxA-
G6M88_RS12830 (G6M88_12850)2666803..2667747-945WP_065698383.1peptidylprolyl isomerase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(8-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14809.14 Da        Isoelectric Point: 6.6961

>T151054 WP_065698385.1 NZ_CP049206:2664515-2664913 [Agrobacterium rubi]
MLTYMLDTNICIYVMKTYPPELRDKFNAMAEQLCISSITLGELCYGAEKSARRNENLVAIDNFVSRLDVLPFADKAAAHY
GQIRAELARAGTPCGVHDMQIGGHARSEGLIVVTNNMREFIRMPGLRVENWV

Download         Length: 399 bp

>T151054 NZ_CP065194:c1790180-1789971 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8812.03 Da        Isoelectric Point: 8.8756

>AT151054 WP_065698386.1 NZ_CP049206:2664282-2664515 [Agrobacterium rubi]
MITSTVFLSNRSQAVRLPKAVAFPEDVHQVDILKIGRTRIIVPHGKRWDDLFASGPRASKDFLSDREQPSAEEREFF

Download         Length: 234 bp

>AT151054 NZ_CP065194:c1790485-1790192 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B9U0G2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B9U0H7

References