Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 2483705..2484330 Replicon chromosome
Accession NZ_CP049206
Organism Agrobacterium rubi strain W2/73

Toxin (Protein)


Gene name mazF Uniprot ID A0A1B9TWC0
Locus tag G6M88_RS11865 Protein ID WP_065698895.1
Coordinates 2483971..2484330 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1B9TWA5
Locus tag G6M88_RS11860 Protein ID WP_065698896.1
Coordinates 2483705..2483971 (+) Length 89 a.a.

Genomic Context

G6M88_RS11830G6M88_RS11845G6M88_RS11850G6M88_RS11855G6M88_RS11860G6M88_RS11865G6M88_RS11870G6M88_RS11880G6M88_RS11835G6M88_RS11840G6M88_RS11875G6M88_RS11885G6M88_RS11890G6M88_RS11895
Location: 2478885..2479700 (816 bp)
Type: Others
Protein ID: WP_065698902.1
Location: 2480455..2482956 (2502 bp)
Type: Others
Protein ID: WP_065698899.1
Location: 2482953..2483363 (411 bp)
Type: Others
Protein ID: WP_065698898.1
Location: 2483390..2483590 (201 bp)
Type: Others
Protein ID: WP_065698897.1
Location: 2483705..2483971 (267 bp)
Type: Antitoxin
Protein ID: WP_065698896.1
Location: 2483971..2484330 (360 bp)
Type: Toxin
Protein ID: WP_065698895.1
Location: 2484339..2484527 (189 bp)
Type: Others
Protein ID: WP_065698894.1
Location: 2484931..2486346 (1416 bp)
Type: Others
Protein ID: WP_162273323.1
Location: 2479704..2479988 (285 bp)
Type: Others
Protein ID: WP_065698901.1
Location: 2480036..2480311 (276 bp)
Type: Others
Protein ID: WP_065698900.1
Location: 2484543..2484791 (249 bp)
Type: Others
Protein ID: WP_065698893.1
Location: 2486341..2486511 (171 bp)
Type: Others
Protein ID: WP_164470675.1
Location: 2486578..2488293 (1716 bp)
Type: Others
Protein ID: WP_065698892.1
Location: 2488354..2488569 (216 bp)
Type: Others
Protein ID: WP_141680619.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G6M88_RS11830 (G6M88_11850)2478885..2479700+816WP_065698902.1penicillin-binding transpeptidase domain-containing protein-
G6M88_RS11835 (G6M88_11855)2479704..2479988-285WP_065698901.1type II toxin-antitoxin system YafQ family toxin-
G6M88_RS11840 (G6M88_11860)2480036..2480311-276WP_065698900.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
G6M88_RS11845 (G6M88_11865)2480455..2482956+2502WP_065698899.1heavy metal translocating P-type ATPase-
G6M88_RS11850 (G6M88_11870)2482953..2483363+411WP_065698898.1Cu(I)-responsive transcriptional regulator-
G6M88_RS11855 (G6M88_11875)2483390..2483590+201WP_065698897.1heavy-metal-associated domain-containing protein-
G6M88_RS11860 (G6M88_11880)2483705..2483971+267WP_065698896.1PbsX family transcriptional regulatorAntitoxin
G6M88_RS11865 (G6M88_11885)2483971..2484330+360WP_065698895.1type II toxin-antitoxin system PemK/MazF family toxinToxin
G6M88_RS11870 (G6M88_11890)2484339..2484527+189WP_065698894.1hypothetical protein-
G6M88_RS11875 (G6M88_11895)2484543..2484791-249WP_065698893.1hypothetical protein-
G6M88_RS11880 (G6M88_11900)2484931..2486346+1416WP_162273323.1MFS transporter-
G6M88_RS11885 (G6M88_11905)2486341..2486511-171WP_164470675.1hypothetical protein-
G6M88_RS11890 (G6M88_11910)2486578..2488293-1716WP_065698892.1GH32 C-terminal domain-containing protein-
G6M88_RS11895 (G6M88_11915)2488354..2488569-216WP_141680619.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12866.06 Da        Isoelectric Point: 8.2958

>T151053 WP_065698895.1 NZ_CP049206:2483971-2484330 [Agrobacterium rubi]
MVRSNVPKRGDVFLIDLNPVIGNEMNDEHRCVVITPKEINAVGLCLVVPITTGGMFTRKAGLAVNISGHRTTGVALCNQV
RSLDIAGRIAQKRAKFLETLDDATIQEIVARVVSMIDPA

Download         Length: 360 bp

>T151053 NZ_CP065194:c1770596-1770234 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9384.86 Da        Isoelectric Point: 4.7389

>AT151053 WP_065698896.1 NZ_CP049206:2483705-2483971 [Agrobacterium rubi]
MTVTTKIRRQGGAAVMTIPPALLKLMGTEIGSEMTLEIDNGNLVATPVTTQKKRYSLAELLEGADEMAELNVEASAWNAA
PRVGKEAL

Download         Length: 267 bp

>AT151053 NZ_CP065194:c1770763-1770593 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1B9TWC0

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1B9TWA5

References