Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 2479704..2480311 Replicon chromosome
Accession NZ_CP049206
Organism Agrobacterium rubi strain W2/73

Toxin (Protein)


Gene name relE Uniprot ID A0A1B9TWE3
Locus tag G6M88_RS11835 Protein ID WP_065698901.1
Coordinates 2479704..2479988 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A1B9TWB2
Locus tag G6M88_RS11840 Protein ID WP_065698900.1
Coordinates 2480036..2480311 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M88_RS11815 (G6M88_11835) 2474830..2475795 - 966 WP_141680620.1 hypothetical protein -
G6M88_RS11820 (G6M88_11840) 2475937..2478108 - 2172 WP_065698904.1 transglycosylase domain-containing protein -
G6M88_RS11825 (G6M88_11845) 2478294..2478770 + 477 WP_065698903.1 YcgN family cysteine cluster protein -
G6M88_RS11830 (G6M88_11850) 2478885..2479700 + 816 WP_065698902.1 penicillin-binding transpeptidase domain-containing protein -
G6M88_RS11835 (G6M88_11855) 2479704..2479988 - 285 WP_065698901.1 type II toxin-antitoxin system YafQ family toxin Toxin
G6M88_RS11840 (G6M88_11860) 2480036..2480311 - 276 WP_065698900.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G6M88_RS11845 (G6M88_11865) 2480455..2482956 + 2502 WP_065698899.1 heavy metal translocating P-type ATPase -
G6M88_RS11850 (G6M88_11870) 2482953..2483363 + 411 WP_065698898.1 Cu(I)-responsive transcriptional regulator -
G6M88_RS11855 (G6M88_11875) 2483390..2483590 + 201 WP_065698897.1 heavy-metal-associated domain-containing protein -
G6M88_RS11860 (G6M88_11880) 2483705..2483971 + 267 WP_065698896.1 PbsX family transcriptional regulator -
G6M88_RS11865 (G6M88_11885) 2483971..2484330 + 360 WP_065698895.1 type II toxin-antitoxin system PemK/MazF family toxin -
G6M88_RS11870 (G6M88_11890) 2484339..2484527 + 189 WP_065698894.1 hypothetical protein -
G6M88_RS11875 (G6M88_11895) 2484543..2484791 - 249 WP_065698893.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-74)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11039.63 Da        Isoelectric Point: 7.3589

>T151052 WP_065698901.1 NZ_CP049206:c2479988-2479704 [Agrobacterium rubi]
MPRSSDFTKQFLKDWKRLNVSGRYDMAKLKAVMLLLIANDATLPAQFRDHELAGEWRDHRECHIGGDFLLIYRLDETDNL
VVFTRTGTHSELFR

Download         Length: 285 bp

>T151052 NZ_CP065194:c1617876-1617724 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10109.75 Da        Isoelectric Point: 4.8537

>AT151052 WP_065698900.1 NZ_CP049206:c2480311-2480036 [Agrobacterium rubi]
MTANAYVRARIDQALKDDATAVLDSLGLTVSDVMRMMLIRIAREKALPIELTRPNAETLAAMEEARAITAEKRARFNMTE
ELFEALDGAKL

Download         Length: 276 bp

>AT151052 NZ_CP065194:c1618500-1617901 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAATATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9TWE3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9TWB2

References