Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2443815..2444401 Replicon chromosome
Accession NZ_CP049206
Organism Agrobacterium rubi strain W2/73

Toxin (Protein)


Gene name hicA Uniprot ID A0A1B9TGY4
Locus tag G6M88_RS11625 Protein ID WP_065699557.1
Coordinates 2444141..2444401 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G6M88_RS11620 Protein ID WP_174003141.1
Coordinates 2443815..2444144 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M88_RS11600 (G6M88_11620) 2439210..2441309 - 2100 WP_065699560.1 S9 family peptidase -
G6M88_RS11605 (G6M88_11625) 2441547..2441948 + 402 WP_065700090.1 DUF930 domain-containing protein -
G6M88_RS11610 (G6M88_11630) 2442107..2443027 + 921 WP_065699559.1 dihydrodipicolinate synthase family protein -
G6M88_RS11615 (G6M88_11635) 2443086..2443811 + 726 WP_065699558.1 polysaccharide deacetylase family protein -
G6M88_RS11620 (G6M88_11640) 2443815..2444144 - 330 WP_174003141.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G6M88_RS11625 (G6M88_11645) 2444141..2444401 - 261 WP_065699557.1 type II toxin-antitoxin system HicA family toxin Toxin
G6M88_RS11630 (G6M88_11650) 2444505..2445671 - 1167 WP_045231227.1 AI-2E family transporter -
G6M88_RS11635 (G6M88_11655) 2445752..2446612 - 861 WP_065700088.1 VOC family protein -
G6M88_RS11640 (G6M88_11660) 2446768..2448027 - 1260 WP_065700087.1 glycosyltransferase -
G6M88_RS11645 (G6M88_11665) 2448318..2448986 + 669 WP_045231224.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-84)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9477.85 Da        Isoelectric Point: 11.0845

>T151051 WP_065699557.1 NZ_CP049206:c2444401-2444141 [Agrobacterium rubi]
MNLSRRHQAVLEAIFSDPVKAGIVWRDVEALFQACGADVSEGQGSRVRVALNGVRAVFHRPHPQKETDKGAVKSVRRFLS
EAGIRP

Download         Length: 261 bp

>T151051 NZ_CP065194:721001-721108 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12109.55 Da        Isoelectric Point: 4.5212

>AT151051 WP_174003141.1 NZ_CP049206:c2444144-2443815 [Agrobacterium rubi]
MSVMHYKGYEAVIEFDEDADLFHGEVIDLRDVITFQGSSASELKTALAESVEDYLAFCAERGEEPEKPFSGQFVVRTEPR
LHKAVSNAARKDGVSLNKWVTAALERAVS

Download         Length: 330 bp

>AT151051 NZ_CP065194:c721217-721103 [Staphylococcus aureus]
TAAAAAGACGACATGCAGTAACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGACTAAATGAGATTTGCTTTAACCAT
CATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9TGY4

Antitoxin

Source ID Structure

References