Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1066760..1067416 Replicon chromosome
Accession NZ_CP049206
Organism Agrobacterium rubi strain W2/73

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B9T626
Locus tag G6M88_RS05205 Protein ID WP_065701614.1
Coordinates 1066760..1067122 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B9T634
Locus tag G6M88_RS05210 Protein ID WP_065701615.1
Coordinates 1067159..1067416 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M88_RS05180 (G6M88_05180) 1062411..1063016 + 606 WP_202032556.1 LysE family transporter -
G6M88_RS05185 (G6M88_05185) 1063091..1063471 + 381 WP_065701449.1 transcriptional regulator -
G6M88_RS05190 (G6M88_05190) 1063508..1064173 - 666 WP_065701450.1 DJ-1/PfpI family protein -
G6M88_RS05195 (G6M88_05195) 1064256..1065212 + 957 WP_065701451.1 GlxA family transcriptional regulator -
G6M88_RS05200 (G6M88_05200) 1065282..1066739 - 1458 WP_065701452.1 glutamate synthase subunit beta -
G6M88_RS05205 (G6M88_05205) 1066760..1067122 - 363 WP_065701614.1 type II toxin-antitoxin system VapC family toxin Toxin
G6M88_RS05210 (G6M88_05210) 1067159..1067416 - 258 WP_065701615.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G6M88_RS05215 (G6M88_05215) 1067473..1072212 - 4740 WP_065701453.1 glutamate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-111)

Antitoxin

SpoVT-AbrB domain

(12-58)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13444.67 Da        Isoelectric Point: 9.7874

>T151048 WP_065701614.1 NZ_CP049206:c1067122-1066760 [Agrobacterium rubi]
MMRNPQGKVFQRIAKVGEDAVLTSIIVSCEVRFGIEKRQSEKLAKRFSDVFGTLSVKRLDTTVEGHYAVIRTKLEAMGNP
IGQMDMLIAAHALALDAVVVTDNEREFSRVPGLKVENWLR

Download         Length: 363 bp

>T151048 NZ_CP065178:c4104065-4103178 [Pectobacterium quasiaquaticum]
ATGCTGAAGCAACAAATTCGCCAAATCGTCCAGTCAAACCCTGACTATGCCGCAGTGACACCCGTCATAGAAAAAGAGAT
CTTGCATCATGACATTATAGATGTGCTGATCAAACAGGGTGTCATGCAACGGTTAACGTTTATTGGCGGCACCTCATTAC
GAATGTGTTACAACAGTAGCAGGCTATCAGAAGACCTTGATTTCAATGGTGGTCATGATTTCAAGCCCTCAGCATTTGAG
GGGCTGGAATCCGAGATCCAAACCTATATTCAGAACAAGTATGAAACCGAAGTTTGGGTAAACAAACCTTCTGGCGAGCA
GCAAGGGGATACCGTTTCTTGGAAAATTAGTATCGTAAAAGAAGCGAATCGTCCTGATTTGCCACGGCAAAAAATGCATA
TTGATGTCTGTGCTATTCCATCATTTGATATTGAAAAGCGCCCGCTAATCAATCATTACGACATTGTTGTACCGACTGAA
GGGATCTTGGTTCCGGTACAATCGTTACAAGAAACACTAGCCGATAAGCTGATCGCGTTAGCGTATCGGGCAAGACGTAT
AAAGCCTCGTGATATCTGGGATATTGTTTGGATTAAGCAGCGCGGCATTGATCTATCCAAAACACTGGTTGAAAAGAAAC
TCACCGCCAGACACAAGCAAACAGATGACTTTCGACAGGCGCTATCTATTCAGTTAGCTAAGTTAATGTCGCAAGATGAA
GTCCGTGACGACTTTAATATGGAAATGAGCCGCTTTATCCCTAAGCAAATTAAAGAGAGAACCCTCGATAATCCCGAATA
TTGGGATTATGTTCAGAGAGAGGTACATGCCATCACGTCTGAGTTATTGAATGACGTAACACCAAAAAATCCATTTGATA
TGGGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9823.05 Da        Isoelectric Point: 3.9682

>AT151048 WP_065701615.1 NZ_CP049206:c1067416-1067159 [Agrobacterium rubi]
MNVVKIAQVFNNGRSRAIRIPKEFEFEADQVEISMNENGDLLVHPVKKRSLLELLASLEPLSEEDWMPEIEDYPPEPVDL
GWDED

Download         Length: 258 bp

>AT151048 NZ_CP065178:c4104618-4104094 [Pectobacterium quasiaquaticum]
ATGACTAAATCTGATGAGCTACTAAACGTATTTTCCAAAGCGGTGAACGCTGGCGGTGGCATTCATAGTGCAACAGAGCT
GGCTTTTATGCAGGGTGTGCCATGTGACTCAGCCTTTAGAAAGTTCCTAGCCGATTGCGTAAAGAGGGGGTTGCTAAGAC
GAGTGGTGAAAGGCTTCTATGAAAGTGTTATTACACCACCTGAGCCTGAGACTGCCATTTATAAAATCATCAAAAAGTTG
CGCAGTGGCGTATTGAACTACATCAGTTTAGAAAGCCAGCTCAGTCATACCGGTGATATTTCACAAGTGGTGATGGGTAG
AGTCACGGTAGTGACTAAAGGTCGAAGTGGTTGTTTTGATACGCCTTATGGCGTGATTGAGTTTACCCATACTAAAAAGC
CAGTCGAGCAAGTTGCACCTAATTTGTACTATGACCCTGACATTAAAATGTATCGCGCATACAAGGAACAAGCGATTGCA
GATCTAAAGCACTGCCAGCGCAATCTACATATGTTGGAGAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9T626

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9T634

References