Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4272185..4272780 Replicon chromosome
Accession NZ_CP049204
Organism Escherichia coli strain PapM-32-1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag G6Z93_RS20255 Protein ID WP_000239579.1
Coordinates 4272185..4272535 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag G6Z93_RS20260 Protein ID WP_001223208.1
Coordinates 4272529..4272780 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Z93_RS20235 4267631..4268653 - 1023 WP_001297255.1 ABC transporter permease -
G6Z93_RS20240 4268667..4270169 - 1503 WP_032185911.1 sugar ABC transporter ATP-binding protein -
G6Z93_RS20245 4270309..4271265 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
G6Z93_RS20250 4271575..4272105 + 531 WP_000055072.1 inorganic diphosphatase -
G6Z93_RS20255 4272185..4272535 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
G6Z93_RS20260 4272529..4272780 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
G6Z93_RS20265 4272992..4273333 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
G6Z93_RS20270 4273336..4277115 - 3780 WP_164476797.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T151038 WP_000239579.1 NZ_CP049204:c4272535-4272185 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T151038 NZ_CP065178:c1254207-1253863 [Pectobacterium quasiaquaticum]
ATGAAATCACTCTACTGGGTTGGCAGTAGCAAAAAGGATCTCCAGTCGCTACCTGCTGATGTGCAGGATGTGTTCGGTTA
CGCACTTCATGTGGCTCAGACTGGTGGTAAGCACATTCAAGCCAAGCCGCTTAAAGGTTTTGGTGGTGCAGGCGTATTAG
AAGTCGTTGAGGATTATATCGGCGATACTTATCGCGCAGTCTACACCGTCAAATTTGGAGAGTCAGTATACGTTCTACAT
GCTTTTCAGAAAAAATCGTCATCTGGCATTGCAACACCGAAACCCGATATGAACACCATTCGTGAACGCCTTAAAGCCGC
AGAAAACCATGCAAAAGGAGCATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT151038 WP_001223208.1 NZ_CP049204:c4272780-4272529 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT151038 NZ_CP065178:c1253861-1253544 [Pectobacterium quasiaquaticum]
ATGAGCCAAGATATTGAAGTCAGCAGTGGTAATGTGTACGCCGACCTTGGCAACGTGCATGCTGAAGATATGTTGGTCAA
AGCGCAGCTTGCCACCCTGATTAGCTCAATCATCAAAAGCCGCCGTCTCACACAGGCAGAAGCAGCGAAGCTATTGGGCA
TGCCCCAACCCAAACTATCCAACTTATTACGTGGTCAGTTCAGGGGAATCAGTGAAACCAAAATGCTGGAATGCCTCACG
AAGCTGGGACGCGATATACAGATCGTGGTAGGGAAACCGCGCCGCACGCCGGGTAGCGTTAAAGTCGTGTTTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References