Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4202201..4203884 | Replicon | chromosome |
| Accession | NZ_CP049204 | ||
| Organism | Escherichia coli strain PapM-32-1 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | G6Z93_RS19915 | Protein ID | WP_164476773.1 |
| Coordinates | 4202967..4203884 (+) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | G6Z93_RS19910 | Protein ID | WP_164476772.1 |
| Coordinates | 4202201..4202974 (+) | Length | 258 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6Z93_RS19895 | 4198058..4200142 | + | 2085 | WP_001193073.1 | protease Lon-related BREX system protein BrxL | - |
| G6Z93_RS19900 | 4200261..4201610 | + | 1350 | WP_164476771.1 | phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase family protein | - |
| G6Z93_RS19905 | 4201786..4202114 | - | 329 | Protein_3892 | IS3 family transposase | - |
| G6Z93_RS19910 | 4202201..4202974 | + | 774 | WP_164476772.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| G6Z93_RS19915 | 4202967..4203884 | + | 918 | WP_164476773.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| G6Z93_RS19920 | 4204398..4205060 | - | 663 | WP_164476774.1 | hypothetical protein | - |
| G6Z93_RS19925 | 4205064..4205774 | - | 711 | Protein_3896 | integrase arm-type DNA-binding domain-containing protein | - |
| G6Z93_RS19930 | 4206157..4207164 | - | 1008 | WP_164476775.1 | restriction endonuclease | - |
| G6Z93_RS19935 | 4207423..4207764 | - | 342 | WP_164476776.1 | TA system toxin CbtA family protein | - |
| G6Z93_RS19940 | 4207785..4208126 | - | 342 | WP_164476777.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| G6Z93_RS19945 | 4208137..4208679 | - | 543 | WP_164476778.1 | DNA repair protein RadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4202201..4229434 | 27233 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34886.00 Da Isoelectric Point: 4.8329
>T151036 WP_164476773.1 NZ_CP049204:4202967-4203884 [Escherichia coli]
MDKTSPYYRQVALLVRALPWVANESCFALKGGTAINLFIHDFPRLSVDIDLAWIPLESREVALPNVREALTRIAAELEAQ
TGIHAVLQTHNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDIVGAVEEEFGFAALPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRSIFNGFIAYLLSHNRPLSEVLNPRWKDITEPFQNEFSGMTFEEISLEELKEVPERMLSTLKT
HFTQQDFDFLMSFKRGEPDWNLAPEPHIQNLPAVQWKLRNIGQMSEEKRAQSLEKLEKVMTKWLL
MDKTSPYYRQVALLVRALPWVANESCFALKGGTAINLFIHDFPRLSVDIDLAWIPLESREVALPNVREALTRIAAELEAQ
TGIHAVLQTHNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDIVGAVEEEFGFAALPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRSIFNGFIAYLLSHNRPLSEVLNPRWKDITEPFQNEFSGMTFEEISLEELKEVPERMLSTLKT
HFTQQDFDFLMSFKRGEPDWNLAPEPHIQNLPAVQWKLRNIGQMSEEKRAQSLEKLEKVMTKWLL
Download Length: 918 bp
>T151036 NZ_CP065178:1043752-1044096 [Pectobacterium quasiaquaticum]
ATGTGGACGGTAGTTTTGACGGAACGATTTACCGCATGGTTAGAAGAACAGGAAGGTTCTCTACAGGAAAAAATGGCGGC
TGACCTGATGCGCCTTGAATTTTATGGCCCACAGCTTCCCCGCCCCTACGCTGACGGCGTGAAAGGTTCACGCTATCGCA
ATATGAAAGAATTGCGCGTGCAACATGCCGGGCACCCAATTCGAGCTTTCTTTGCTTTCGATCCCGAGCGTCAGGCTATC
GTGTTGTGTGCCGGGGACAAAAGCAATGATAAGCGGTTTTATGACACCATGATCCGTATCGCGGATGATGAATTTACCGA
GCATCTGGCAAAGAGGAATCACTAA
ATGTGGACGGTAGTTTTGACGGAACGATTTACCGCATGGTTAGAAGAACAGGAAGGTTCTCTACAGGAAAAAATGGCGGC
TGACCTGATGCGCCTTGAATTTTATGGCCCACAGCTTCCCCGCCCCTACGCTGACGGCGTGAAAGGTTCACGCTATCGCA
ATATGAAAGAATTGCGCGTGCAACATGCCGGGCACCCAATTCGAGCTTTCTTTGCTTTCGATCCCGAGCGTCAGGCTATC
GTGTTGTGTGCCGGGGACAAAAGCAATGATAAGCGGTTTTATGACACCATGATCCGTATCGCGGATGATGAATTTACCGA
GCATCTGGCAAAGAGGAATCACTAA
Antitoxin
Download Length: 258 a.a. Molecular weight: 29187.59 Da Isoelectric Point: 9.9889
>AT151036 WP_164476772.1 NZ_CP049204:4202201-4202974 [Escherichia coli]
MASKLNWLLQNTSPGSLVLQSWLTRNNISPSLAFKYAQNGWLIKLRAGVYARAGREPDWSDALWCLQNQLEAPVHLAGLS
SLSWLGRSHYLQLKQGQCWLSAENKAILPKWFKEFPGVEWLVVSALKLPDLDEKYRTELEVKGKRITASTPELAAYELLS
AVPQEISFEHAAELFQGLVNLNPRKVEKLLTLSQSVQTKRLYLFFASFYEHAWFKRIDTSKINLGSGNRQIVVNGKLNTQ
YQITVPENFTKKGISHG
MASKLNWLLQNTSPGSLVLQSWLTRNNISPSLAFKYAQNGWLIKLRAGVYARAGREPDWSDALWCLQNQLEAPVHLAGLS
SLSWLGRSHYLQLKQGQCWLSAENKAILPKWFKEFPGVEWLVVSALKLPDLDEKYRTELEVKGKRITASTPELAAYELLS
AVPQEISFEHAAELFQGLVNLNPRKVEKLLTLSQSVQTKRLYLFFASFYEHAWFKRIDTSKINLGSGNRQIVVNGKLNTQ
YQITVPENFTKKGISHG
Download Length: 774 bp
>AT151036 NZ_CP065178:1044096-1044395 [Pectobacterium quasiaquaticum]
ATGAAAACGCTCAAAGATTTTATTGCGGCGCAGTCACCAGAAAGTCAGGCCCGCATTAAAGAAATGGCCGATGAAATGAT
TCTGGAAACGGGCCTACAGATGTTGAGGGAAGAACTCCAGCTTTCACAAAAAACCGTTGCCGATGCGATGGGGATTAAAC
AGCCCGCGATCACTCAGATAGAACAGCGCGGTAACGATGTCAAACTGGCAACGTTGAAACGCTATATTGAAGCGATGGGC
GGCAAGTTAAGCCTGACGGTTGAACTACCGGATGGCGGCGGGCGGGTATTCCATATCTGA
ATGAAAACGCTCAAAGATTTTATTGCGGCGCAGTCACCAGAAAGTCAGGCCCGCATTAAAGAAATGGCCGATGAAATGAT
TCTGGAAACGGGCCTACAGATGTTGAGGGAAGAACTCCAGCTTTCACAAAAAACCGTTGCCGATGCGATGGGGATTAAAC
AGCCCGCGATCACTCAGATAGAACAGCGCGGTAACGATGTCAAACTGGCAACGTTGAAACGCTATATTGAAGCGATGGGC
GGCAAGTTAAGCCTGACGGTTGAACTACCGGATGGCGGCGGGCGGGTATTCCATATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|