Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3515413..3516031 Replicon chromosome
Accession NZ_CP049204
Organism Escherichia coli strain PapM-32-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6Z93_RS16695 Protein ID WP_001291435.1
Coordinates 3515813..3516031 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag G6Z93_RS16690 Protein ID WP_000344800.1
Coordinates 3515413..3515787 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Z93_RS16680 3510502..3511695 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G6Z93_RS16685 3511718..3514867 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
G6Z93_RS16690 3515413..3515787 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
G6Z93_RS16695 3515813..3516031 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
G6Z93_RS16700 3516203..3516754 + 552 WP_000102564.1 maltose O-acetyltransferase -
G6Z93_RS16705 3516870..3517340 + 471 WP_000136192.1 YlaC family protein -
G6Z93_RS16710 3517504..3519054 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
G6Z93_RS16715 3519096..3519449 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G6Z93_RS16725 3519828..3520139 + 312 WP_000409909.1 MGMT family protein -
G6Z93_RS16730 3520170..3520742 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151034 WP_001291435.1 NZ_CP049204:3515813-3516031 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T151034 NZ_CP065178:464057-464362 [Pectobacterium quasiaquaticum]
ATGCCACAAGTGATCGTTTCAGAACGCGCGAAGCGTGATTTGCAGCGTCTGCAGGATTTTCTAAAAAACAAAAATGCGCT
GGCTGCGAAAAAGGCCGCTGAAGTTTTGATTCGCGGCATTCGTCAGTTAGAAGCGCTGCCGAATATCGGGCGACCCGTTG
AACATCTCCCTCTTGAATATCAGGAACTGGTGATCGAATTCGGCAGCAGCGGGTACGTGATGCTTTACCGTCATGATGAA
CTGACTGACAGAGTGGTGATCCTGACCGTCAAGCATCAAAAAGAAGCCGGTTACCAAAACCCTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT151034 WP_000344800.1 NZ_CP049204:3515413-3515787 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT151034 NZ_CP065178:463779-464069 [Pectobacterium quasiaquaticum]
ATGGCTGACACCACACGTCAAACCACGACGCTGCGCATCGATCAGGACATTAAGGAACGACTGAAAACGCTGGCCGATGA
CCGCAACAGCTCAGCCCATGCGCTGATGCTGGAAGCGATTGCCGAATACGTTGAGCGGGAAGAAAAACGCAGCCAGTACC
GTAAAGAGGCGTTGGCCGCGTGGGAAGACTATCAGGACACTGGCAAACATATCACTGCAGATGAAACCGTTACCTGGTTA
GAATCTTGGGGTTCTGGACATGAACAGGATGCGCCTGCATGCCACAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References