Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2412613..2413251 Replicon chromosome
Accession NZ_CP049204
Organism Escherichia coli strain PapM-32-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G6Z93_RS11420 Protein ID WP_105463384.1
Coordinates 2413075..2413251 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G6Z93_RS11415 Protein ID WP_001270286.1
Coordinates 2412613..2413029 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Z93_RS11395 2407765..2408706 - 942 WP_001251315.1 ABC transporter permease -
G6Z93_RS11400 2408707..2409720 - 1014 WP_097470262.1 ABC transporter ATP-binding protein -
G6Z93_RS11405 2409738..2410883 - 1146 WP_164476549.1 ABC transporter substrate-binding protein -
G6Z93_RS11410 2411128..2412534 - 1407 WP_164476550.1 PLP-dependent aminotransferase family protein -
G6Z93_RS11415 2412613..2413029 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
G6Z93_RS11420 2413075..2413251 - 177 WP_105463384.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
G6Z93_RS11425 2413473..2413703 + 231 WP_164476551.1 YncJ family protein -
G6Z93_RS11430 2413795..2415756 - 1962 WP_164476552.1 23S rRNA 5-hydroxycytidine C2501 synthase -
G6Z93_RS11435 2415829..2416365 - 537 WP_000429147.1 DNA-binding transcriptional regulator SutR -
G6Z93_RS11440 2416418..2417629 + 1212 WP_164476553.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6682.71 Da        Isoelectric Point: 10.3186

>T151033 WP_105463384.1 NZ_CP049204:c2413251-2413075 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPCHPCDEINEPLRKAILKQLGLS

Download         Length: 177 bp

>T151033 NZ_CP065178:362049-362336 [Pectobacterium quasiaquaticum]
ATGACCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAGCTAGGGCATCCTGTCCGTGAGCAGTTCAA
GAAAAAGCTGGTTGAGCGTTTGGAAAATCCTCGTGTTCCTTCAGCCCAGCTTCATGGCCGTAAAGACCAGTATAAAATTA
AACTGAAGTCCGCTGGCTACAGGCTGGTGTATTTGGTCCAGGATGAGACCATCACTGTGATGGTTATGGGAGTTGGAAAG
CGCGAAGGTAGCCAGATTTATTCTGATACGAAAGGTCGCTCTGCTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT151033 WP_001270286.1 NZ_CP049204:c2413029-2412613 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT151033 NZ_CP065178:361805-362059 [Pectobacterium quasiaquaticum]
ATGGCTTTCAACATCCTAACTAACACAGCCGCCAGTATTACTGAGTTGAAACGTGACCCGATGGGGACGGTACGGGCTGC
TGAAGGTGAAACTATCGCTATACTGAACCGGAATGAGCCGGCGTTCTACTGTGTGCCTCCTGCCGTATTCGCTTATTTAA
TGGAATTGGCTGAAGATGCAGAGCTGGGGCGTACCGTTGATGATCGGATGTCAGAGCTAGCTGACGCGGAAGAGATTTCG
CTCGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References