Detailed information of TA system TA151023

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1188821..1189493
• Replicon: chromosome
• Accession: NZ_CP049204
• Organism: Escherichia coli strain PapM-32-1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: G6Z93_RS05670
• Protein ID: WP_097482550.1
• Coordinates: 1188821..1189141 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: G6Z93_RS05675
• Protein ID: WP_046081138.1
• Coordinates: 1189173..1189493 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6Z93_RS05670	1188821..1189141	-	321	WP_097482550.1	TA system toxin CbtA family protein	Toxin
G6Z93_RS05675	1189173..1189493	-	321	WP_046081138.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
G6Z93_RS05680	1189511..1189732	-	222	WP_126508362.1	DUF987 family protein	-
G6Z93_RS05685	1189740..1190213	-	474	WP_021555650.1	DNA repair protein RadC	-
G6Z93_RS05690	1190246..1191064	-	819	WP_042004043.1	DUF945 domain-containing protein	-
G6Z93_RS05695	1191461..1192132	+	672	WP_164476411.1	inovirus Gp2 family protein	-
G6Z93_RS05700	1192447..1193859	+	1413	WP_075842266.1	DUF3987 domain-containing protein	-
G6Z93_RS05705	1194125..1194403	+	279	WP_052232689.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1181473..1207120	25647

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-105)

Antitoxin

• Antitoxin CbeA (4-102)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12018.68 Da
• Isoelectric Point: 5.4732

>T151023 WP_097482550.1 NZ_CP049204:c1189141-1188821 [Escherichia coli]
MHILSVPTTVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIEAGITLADAVNFLVEKYELVRIDRKGF
SWQDQTPFLSATDILRARRATGIMST

Nucleotide

• Length: 321 bp

>T151023 NZ_CP065177:3446441-3446746 [Pectobacterium quasiaquaticum]
ATGCAATTCATTGTTTATCAATACAAACGAACCAGTCACTATAAAATGTTTGTCGATGTGCAAAGCGATCTTGTCGAGAC
GCCCAAGCGGCGCATGGTCATTCCGCTTATCGAATCACATCACTTGTCTGAGAAAGTGAATAAAACATTGTTCCCTCAGC
TCCGCATCGACGGCGAAGATTATCGGCTGATGACCACTGAGCTATCGAGCGTTCCCGTTGAGGTCATTGGTGAAGTGATT
GCGGATCTTGGCGACTACGCGGATGAAATAAAGGATGCTATTAATCTGATGTTTTGGGGGATTTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11996.70 Da
• Isoelectric Point: 6.5930

>AT151023 WP_046081138.1 NZ_CP049204:c1189493-1189173 [Escherichia coli]
MKNSWGLKRDMTPCFGARLVQEGCRLHFLADRADISGAFNEEEALRLDQAFPLVMKQLELMLTTGELHPRHQHCVTLHHN
GLTCEADTLGSHGYVYIVIYPQTSSQ

Nucleotide

• Length: 321 bp

>AT151023 NZ_CP065177:3446220-3446438 [Pectobacterium quasiaquaticum]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGCATCAAGGCTGAGGAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAGCATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA