Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3109286..3110084 Replicon chromosome
Accession NZ_CP049201
Organism Escherichia coli strain PapRG-04-4

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag G6Z99_RS15280 Protein ID WP_160514499.1
Coordinates 3109286..3109663 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag G6Z99_RS15285 Protein ID WP_164475827.1
Coordinates 3109710..3110084 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Z99_RS15240 3104293..3104784 - 492 WP_001383029.1 DUF1097 domain-containing protein -
G6Z99_RS15245 3104886..3105440 - 555 WP_001001902.1 molecular chaperone YcdY -
G6Z99_RS15250 3105464..3106201 - 738 WP_000283664.1 zinc-binding phosphatase -
G6Z99_RS15255 3106256..3107194 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
G6Z99_RS15265 3107665..3108507 - 843 WP_001280481.1 DUF4942 domain-containing protein -
G6Z99_RS15270 3108592..3108789 - 198 WP_000839282.1 DUF957 domain-containing protein -
G6Z99_RS15275 3108801..3109289 - 489 WP_164475439.1 hypothetical protein -
G6Z99_RS15280 3109286..3109663 - 378 WP_160514499.1 TA system toxin CbtA family protein Toxin
G6Z99_RS15285 3109710..3110084 - 375 WP_164475827.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G6Z99_RS15290 3110159..3110380 - 222 WP_000692300.1 DUF987 domain-containing protein -
G6Z99_RS15295 3110449..3110925 - 477 WP_001424026.1 RadC family protein -
G6Z99_RS15300 3110941..3111426 - 486 WP_001563926.1 antirestriction protein -
G6Z99_RS15305 3111518..3112336 - 819 WP_164475828.1 DUF945 domain-containing protein -
G6Z99_RS15310 3112611..3113066 - 456 WP_097754558.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14090.11 Da        Isoelectric Point: 8.7453

>T150998 WP_160514499.1 NZ_CP049201:c3109663-3109286 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCNAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T150998 NZ_CP065172:350345-350692 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13782.53 Da        Isoelectric Point: 6.4761

>AT150998 WP_164475827.1 NZ_CP049201:c3110084-3109710 [Escherichia coli]
VSDTLHETTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYSTLAPATTS

Download         Length: 375 bp

>AT150998 NZ_CP065172:350692-350991 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References